Neoadjuvant docetaxel, capecitabine and cisplatin (DXP) in patients with unresectable locally advanced or metastatic gastric cancer

Annals of Surgical Oncology
Sun Jin SymYoon-Koo Kang

Abstract

This phase II study was conducted to evaluate the efficacy of neoadjuvant chemotherapy with docetaxel, cisplatin and capecitabine (DXP) in patients with unresectable locally advanced and/or intra-abdominal metastatic gastric cancers. Patients with advanced gastric cancer (AGC), clinically unresectable because of local invasion or limited intra-abdominal metastasis in para-aortic lymph nodes and/or the peritoneum based on multidetector row computed tomography, were enrolled. DXP consisted of docetaxel 60 mg/m(2) i.v. and cisplatin 60 mg/m(2) i.v. on day 1, and capecitabine 937.5 mg/m(2) twice daily p.o. on days 1-14 every 21 days. Surgery was performed after 4-6 cycles of DXP. Thirty-six (74%) of the 49 patients enrolled underwent surgery, and 31 (63%) had an R0 resection. R0 resection was possible in 15 of 21 patients (71%) with unresectable locally advanced lesions, 12 of 17 patients (70%) with para-aortic lymph node metastasis but only 4 of 11 patients (36%) with peritoneal metastasis. Grade 3/4 toxicities included neutropenia (69%), febrile neutropenia (4%) and hand-foot syndrome (8%). Neoadjuvant DXP may offer a reasonable chance of curative surgery in AGC patients with unresectable locally advanced or para-aortic lymph nod...Continue Reading

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Citations

Dec 15, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shinkyo YoonYoon-Koo Kang
Feb 22, 2013·Journal of Gastroenterology and Hepatology·Yi LiaoJian-ping Wang
Nov 2, 2013·The Lancet Oncology·Lin ShenLi-Tzong Chen
May 17, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Dong Hoe KooYoon-Koo Kang
Nov 11, 2016·World Journal of Gastrointestinal Surgery·Anneriet E DassenHans J F M Pruijt
Mar 4, 2010·Cancer Chemotherapy and Pharmacology·Fernando RiveraUNKNOWN Spanish Cooperative Group for Digestive Tumour Therapy (TTD)
Jan 6, 2016·World Journal of Gastroenterology : WJG·Osamu KinoshitaEigo Otsuji
Mar 7, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Vincent Chee Ee PhuaWan Zamaniah Wan Ishak
Aug 2, 2019·World Journal of Gastrointestinal Oncology·Osamu Maeda, Yuichi Ando

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