Neoadjuvant hyperfractionated chemoradiation and liver transplantation for unresectable perihilar cholangiocarcinoma in Canada

Journal of Surgical Oncology
Benjamin P T LovedayCarol-Anne Moulton

Abstract

Neoadjuvant chemoradiation and liver transplantation may be offered for unresectable perihilar cholangiocarcinoma (pCCA). This study aimed to determine the dropout rate and survival of patients who entered a national tri-modality protocol. Patients enrolled Jan 2009-Aug 2015 were included. Enrolment criteria: ≤65 years, brush biopsy-proven unresectable pCCA <3.5 cm diameter. Conformal radiotherapy was given concurrently with Capecitabine. Following surgical staging, patients received maintenance Cisplatin and Gemcitabine until transplant or progression. Time to event analyses were performed from start of neoadjuvant therapy. Of 43 patients screened, 18 started treatment; median age 53.9 (26.7-62.8) years, tumour diameter 2.7 (2.0-3.4) cm. 11/18 dropped out due to metastatic disease identified during chemoradiation (n = 2), surgical staging (n = 6), or maintenance chemotherapy (n = 3). Six patients underwent transplantation. Median follow up was 17.6 (4.9-57.7) months and overall survival 16.4 months. One and two year survival was 70.6% and 35.3%, respectively. One and 2 year post transplant survival was 83.3% and 55.6%. Median progression free survival was 11.5 months. Neoadjuvant chemoradiation and liver transplantation for un...Continue Reading

References

Oct 31, 2002·Surgery·Attila NakeebHenry A Pitt
Jun 12, 2004·Seminars in Liver Disease·Julie K HeimbachCharles B Rosen
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
May 26, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Charles B RosenGregory J Gores
Aug 25, 2010·International Journal of Radiation Oncology, Biology, Physics·Michael VelecKristy K Brock
Oct 12, 2012·Langenbeck's Archives of Surgery·Silke SchüleUtz Settmacher
Mar 1, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sarwa Darwish MuradW Ray Kim
Apr 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexis BujoldLaura A Dawson
Apr 23, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sophie DuignanOscar Traynor
Oct 12, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Theodore H WellingChristopher J Sonnenday
Jul 15, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·John C MansourJean-Nicolas Vauthey

❮ Previous
Next ❯

Citations

Apr 17, 2020·Current Oncology Reports·Guergana G PanayotovaKeri E Lunsford
Sep 13, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jeongshim LeeChai Hong Rim
May 31, 2019·Current Treatment Options in Oncology·Nadia AshaiLakshmi Rajdev
Jul 17, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ek Khoon TanCharles B Rosen
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Phillipe AbreuGonzalo Sapisochin
Nov 13, 2019·Transplantation Reviews·Nikolaos MachairasDimitrios Moris
Mar 10, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Minas BaltatzisAjith K Siriwardena
Jan 16, 2022·ESMO Open·A LamarcaL Goyal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.