Neoadjuvant intraarterial infusion chemotherapy with a combination of mitomycin-C, vincristine, and cisplatin for locally advanced cervical cancer: a preliminary report

Gynecologic Oncology
N ItohT Tamaya


Combination chemotherapy including cisplatin was administered intraarterially from the internal iliac artery as neoadjuvant chemotherapy to six patients with locally advanced uterine cervical cancer (stage higher than IIIB of FIGO). The drugs and doses were mitomycin-C 10 mg/m2, vincristine 1 mg/m2, and cisplatin 50 mg/m2. Two or three courses were repeated at intervals of 3 weeks. In three patients, dose reductions were undertaken for decreased renal function and thrombocytopenia. Partial response was, however, observed in all patients (response rate 100%), and five of six patients were able to undergo a radical hysterectomy. The major toxic effects were leukocytopenia, nausea, and vomiting. Our preliminary experience suggests that pelvic intraarterial infusion of combination chemotherapy is effective against primary and advanced uterine cervical cancer, and this preoperative treatment can lead to easier radical hysterectomy. However, further studies are warranted.


Jan 16, 2007·European Radiology·Takashi KoyamaKaori Togashi
Aug 30, 2008·Surgical Oncology Clinics of North America·Takeshi MaruoYonson Ku
Apr 30, 1998·Journal of Magnetic Resonance Imaging : JMRI·K TogashiJ Konishi
Mar 10, 2001·Cancer Treatment Reviews·W T Bradner

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