Neoadjuvant radiotherapy in the approach of locally advanced breast cancer.

ESMO Open
Cláudia SousaPaula Alves

Abstract

Approximately 4% of European patients are diagnosed with locally advanced breast cancer (LABC), a clinical condition commonly associated with poorer prognosis. Systemic therapy is the recommended initial treatment and when inoperability criteria prevails, radiotherapy (RT) should be used for tumour downstaging. This study intends to evaluate the impact of neoadjuvant radiotherapy (NART) in the treatment of inoperable LABC. A retrospective study of female patients, submitted to the NART between January 2014 and December 2018 at our institution. The evaluation of pathological response (pR) was made based on Pinder criteria. Primary endpoint: pR. Secondary endpoints: overall survival (OS) and progression-free survival (PFS). OS and PFS were calculated using the Kaplan-Meier method. Differences between groups were compared using Student's t-test, ANOVA (Analysis of variance) and χ2 test. The statistical analyses were performed using Stata (V.13). A total of 76 patients were included, 18% with breast complete response. The 5 years OS was 54% and PFS was 61%. Subgroup analysis showed that pR >90% is correlated with a better OS (p=0.004). Basal-like intrinsic subtype is correlated with worse OS and PFS (p<0.05). No relation was found ...Continue Reading

References

Mar 1, 1978·International Journal of Radiation Oncology, Biology, Physics·E D Montague
May 1, 1991·Clinical Oncology : a Journal of the Royal College of Radiologists·V Shanta, S Krishnamurthi
Dec 1, 1984·International Journal of Radiation Oncology, Biology, Physics·A M ChuB Curran
Sep 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V F SemiglazovO F Chepic
Jul 28, 2001·International Journal of Cancer. Journal International Du Cancer·E CalitchiJ P Le Bourgeois
Apr 20, 2006·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rainer SouchonKarl Axel Hartmann
Apr 20, 2007·The Cochrane Database of Systematic Reviews·J S D MieogC J H van de Velde
Aug 19, 2007·The British Journal of Surgery·J S D MieogC J H van de Velde
Feb 6, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelia LiedtkeLajos Pusztai
May 27, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J MathewJ F R Robertson
Jul 14, 2009·Radiation Oncology·Alberto Alvarado-MirandaFernando Lara-Medina
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunter von MinckwitzSibylle Loibl
Jul 19, 2014·The Breast : Official Journal of the European Society of Mastology·Michael UntchGunter von Minckwitz
Feb 11, 2015·Nature Reviews. Clinical Oncology·Konstantinos TryfonidisFatima Cardoso
Jan 31, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Fraser SymmansGabriel N Hortobagyi
Jul 23, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoE P Winer
Oct 5, 2018·Radiation Oncology·Miljana TanićRadmila Janković

❮ Previous
Next ❯

Citations

Dec 12, 2020·The Journal of Small Animal Practice·B Wustefeld-JanssensH Wilson-Robles
Aug 28, 2021·Journal of Personalized Medicine·James MeehanArran K Turnbull

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The British Journal of Clinical Psychology
Gerard A Riley, Lincoln V Simmonds
The British Journal of Clinical Psychology
R S BucksD L Ashworth
© 2021 Meta ULC. All rights reserved