Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research

Breast Cancer : Basic and Clinical Research
Cigdem Selli, Andrew H Sims

Abstract

Neoadjuvant therapy, where patients receive systemic therapy before surgical removal of the tumour, can downstage tumours allowing breast-conserving surgery, rather than mastectomy. In addition to its impact on surgery, the neoadjuvant setting offers a valuable opportunity to monitor individual tumour response. The effectiveness of standard and/or potential new therapies can be tested in the neoadjuvant pre-surgical setting. It can potentially help to identify markers differentiating patients that will potentially benefit from continuing with the same or a different adjuvant treatment enabling personalised treatment. Characterising the molecular response to treatment over time can more accurately identify the significant differences between baseline samples that would not be identified without post-treatment samples. In this review, we discuss the potential and challenges of using the neoadjuvant setting in translational breast cancer research, considering the implications for improving our understanding of response to treatment, predicting therapy benefit, modelling breast cancer dormancy, and the development of drug resistance.

References

Mar 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RubensJ L Hayward
Dec 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Britta WeigeltLaura J van't Veer
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marco ColleoniAron Goldhirsch
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Fraser SymmansLajos Pusztai
Oct 22, 2008·Breast Cancer Research : BCR·Julie A VendrellPascale A Cohen
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jan 16, 2009·Breast Cancer Research : BCR·Andrew H Sims, John M S Bartlett
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William R MillerJ Michael Dixon
Dec 17, 2009·Breast Cancer Research and Treatment·Larissa A KordeJo Anne Zujewski
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jonathan W Uhr, Klaus Pantel
Jan 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana M Gonzalez-AnguloLajos Pusztai
Feb 4, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Antonio Llombart-CussacVicente Guillem Porta
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunter von MinckwitzSibylle Loibl
Jun 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura J EssermanNola Hylton
Apr 12, 2013·Science Translational Medicine·Lixin ZhangDario Marchetti
Dec 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aditya Bardia, José Baselga
Dec 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiang H-F ZhangC Kent Osborne
Dec 25, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martine J Piccart-Gebhart
Jun 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neill PataniMitch Dowsett
Aug 15, 2014·Nature Reviews. Cancer·María Soledad SosaJulio A Aguirre-Ghiso
Feb 26, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angela DeMicheleLaura J Esserman
Jun 3, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arran K TurnbullJ Michael Dixon
Jul 28, 2015·Lancet·UNKNOWN Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Sep 29, 2015·The New England Journal of Medicine·Joseph A SparanoGeorge W Sledge
Feb 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vinay VaradanLyndsay N Harris
Apr 19, 2016·The Breast Journal·Anne Bruun KrøigårdTorben A Kruse
Dec 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aleix PratEmilio Alba
Jan 31, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Fraser SymmansGabriel N Hortobagyi
Mar 9, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cynthia X MaMatthew J Ellis
Mar 28, 2017·Seminars in Cancer Biology·Jürgen Dittmer
May 13, 2017·Cancer Discovery·Angel L Guerrero-Zotano, Carlos L Arteaga
Jun 15, 2017·Breast Cancer Research and Treatment·Rodrigo GoncalvesMatthew J Ellis
Jul 2, 2017·Breast Cancer Research : BCR·Jan PoleszczukHeiko Enderling
Dec 1, 2017·BMC Cancer·Govindasamy-Muralidharan KarthikJohan Hartman

❮ Previous
Next ❯

Citations

Jun 23, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Kacoli SenCarlos Rinaldi
Nov 22, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ricardo G PastorelloStuart J Schnitt
Jun 3, 2021·Cancers·Covadonga Martí, José Ignacio Sánchez-Méndez

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

NeoSphere
NeoALTTO
ALTTO

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Breast Cancer Research : BCR
Andrew H Sims, John M S Bartlett
The New England Journal of Medicine
David H Sharkis
The New England Journal of Medicine
Abram Recht
The New England Journal of Medicine
Guru Sonpavde
Journal of Medical Imaging and Radiation Sciences
William T TranGregory J Czarnota
© 2022 Meta ULC. All rights reserved