PMID: 9194034May 1, 1997Paper

Neoadjuvant therapy for surgically staged IIIA N2 non-small cell lung cancer (NSCLC)

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
A D EliasD J Sugarbaker

Abstract

Neoadjuvant therapy in patients with Stage IIIA NSCLC is associated with a 50-70% resection rate and a 3-5 year survival of 20-32%, but few trials have required meticulous staging of the mediastinum to ensure homogeneity of the study population. Continuous infusion cisplatin 25 mg/m2/day 1-5, 5-fluorouracil 800 mg/m2/day 2-5, and high-dose leukovorin 500 mg/m2/day 1-5 (PFL) given every 4 weeks achieved a 41% response rate in metastatic NSCLC (Lynch TJ, Kalish LA, Kass F, Strauss G, Elias A, Skarin A, Shulman L, Sugarbaker D, Frei E. Continuous infusion cisplatin, 5-fluorouracil, and leukovorin for advanced non-small cell lung cancer. Cancer 1994; 73: 1171-1176). The regimen was therefore evaluated in 34 patients with pathologic Stage IIIA N2 disease between 3/91 and 10/92. Staging consisted of chest, liver, brain computerized tomography and bone scan, bronchoscopy and surgical mediastinal node mapping. Patients received PFL for 3 cycles, followed by thoracotomy and thoracic radiotherapy (TRT) to 54-60 Gy. Median age was 57 (42-68) years. Demographic factors included: male 56%; adenocarcinoma 59%, squamous cell carcinoma 24%; Stage T3N2 26%, T2N2 56%, and T1N2 18%. No treatment related deaths occurred. Radiographically defined r...Continue Reading

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Citations

Jul 2, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Tomoyuki ShirafujiHiroyoshi Ayabe
Jan 4, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G FriedelH Toomes
Sep 29, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·W EberhardtG Stamatis
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S JabłonkaD Sagan
Feb 15, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M Rita MigliorinoOlga Martelli
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Jun 23, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Guillaume MouilletUNKNOWN Intergroupe Francophone de Cancérologie Thoracique (IFCT)
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