Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma

World Journal of Hepatology
Clifford AkatehJordan M Cloyd

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy and is increasing in incidence. Long-term outcomes are optimized when patients undergo margin-negative resection followed by adjuvant chemotherapy. Unfortunately, a significant proportion of patients present with locally advanced, unresectable disease. Furthermore, recurrence rates are high even among patients who undergo surgical resection. The delivery of systemic and/or liver-directed therapies prior to surgery may increase the proportion of patients who are eligible for surgery and reduce recurrence rates by prioritizing early systemic therapy for this aggressive cancer. Nevertheless, the available evidence for neoadjuvant therapy in ICC is currently limited yet recent advances in liver directed therapies, chemotherapy regimens, and targeted therapies have generated increasing interest its role. In this article, we review the rationale for, current evidence for, and ongoing research efforts in the use of neoadjuvant therapy for ICC.

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Citations

Jan 6, 2021·Journal of Clinical Medicine·Eliza W BealTimothy M Pawlik
Jun 3, 2021·Journal of Clinical Medicine·Guergana PanayotovaKeri E Lunsford
Jun 3, 2021·Journal of Clinical Medicine·Sudha KodaliRafik M Ghobrial
Nov 4, 2021·Expert Review of Anticancer Therapy·D Brock HewittTimothy M Pawlik

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Methods Mentioned

BETA
surgical resection
surgical

Clinical Trials Mentioned

NCT03579771
NCT03867370

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