Neoadjuvant weekly carboplatin and paclitaxel followed by radical hysterectomy for locally advanced cervical cancer: long-term results

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Taisuke MoriJo Kitawaki

Abstract

To determine the long-term effect of neoadjuvant chemotherapy with paclitaxel and carboplatin on a weekly schedule followed by radical surgery for patients with locally advanced cervical cancer. Thirty patients with stage IB2 to IIIB uterine cervical cancer were treated with paclitaxel (60 mg/m) and carboplatin (area under the curve, 2-an area under the time-concentration curve of 2 mg x min/mL based on creatinine clearance) every week for 6 cycles. A radical hysterectomy was performed 6 days after the final administration of neoadjuvant chemotherapy. The patients were followed up, and 5-year progression-free survival (PFS) and overall survival (OS) were evaluated. Of 30 patients, 28 were followed up. The median follow-up period was 55.6 months (range, 26-83 months). An objective response (complete response + partial response) to the treatment was observed in 26 patients (87%; 95% confidence interval, 70%-95%). Two had complete response, 4 had stable disease, and the remaining patients had partial response; progressive disease was not seen in this study. A radical hysterectomy was performed in 28 patients without delay. Thirteen patients with high-risk factors received radiotherapy after surgery. The 5-year PFS and OS rates wer...Continue Reading

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Citations

Sep 25, 2015·Expert Review of Anticancer Therapy·Mariateresa LapresaNicoletta Colombo
Feb 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lin GongZhi-Lan Peng
Mar 13, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Marie Plante
Jun 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroshi TsubamotoShozo Hirota
Jan 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hao WenShumo Cai
Jul 6, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Perry W GrigsbyGiuseppe Del Priore
Jun 3, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rawand SalihiIgnace Vergote
Apr 17, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Charlotte MaeneIgnace Vergote

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