Neoangiogenesis and expression of hypoxia-inducible factor 1alpha, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas

Gynecologic Oncology
Irem Hicran OzbudakElif Pestereli

Abstract

Hypoxia Inducible Factor-1alpha (HIF-1alpha) is a transcriptional factor that activates multiple genes including Vascular Endothelial Growth Factor (VEGF) and glucose transporter-1 (GLUT-1) in response to hypoxia and promotes neoangiogenesis. Expression of HIF-1alpha VEGF, and GLUT-1 were analyzed by immunohistochemistry and microvessel density (MVD) was determined by CD 34 immunostaining in 100 endometrioid type endometrial adenocarcinoma, FIGO Stages I-IV. High expression of HIF-1alpha, VEGF and GLUT-1 were significantly more prevalent in advanced stages than early stages (p<0.001). High expression of HIF-1alpha was found in 100% of Stage III-IV patients, whereas 50% of Stage II and 9% of Stage I patients had high HIF-1alpha expression. Similarly, high VEGF expression was determined in 4% of Stage I and 30% of Stage II patients, however 90% of Stage III-IV patients had high expression of VEGF. Comparing the GLUT-1 scores, it was found that increasing stages correlated with high GLUT-1 expression. Additionally, a statistically significant difference was also noted in MVD between stages (p<0.001). The average MVD of Stage I patients was 31.87+/-7.73. It was found 49.24+/-7.60 in Stage II, and 78.74+/-14.48 in Stage III-IV patie...Continue Reading

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Citations

Jan 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sami K SaarelainenJohanna U Mäenpää
Jul 22, 2009·BMC Cancer·Fu-Yen ChungShiu-Ru Lin
Feb 20, 2010·Obstetrics and Gynecology International·Laura M S SeeberPaul J van Diest
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Oct 28, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dong Wook LeeYoon Soon Lee
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Marlene PasquetBettina Couderc
Feb 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Keiichiro NakamuraYuji Hiramatsu
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May 11, 2017·Brazilian Oral Research·Rafaella Bastos LeiteCassiano Francisco Weege Nonaka
Jul 16, 2010·Critical Reviews in Oncology/hematology·Laura M S SeeberPaul J van Diest

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