Neoangiogenesis in Melanoma: An Issue in Biology and Systemic Treatment.

Frontiers in Immunology
Davide Quaresmini, Michele Guida

Abstract

Neoangiogenesis is a recognized hallmark of cancer, granting tumor cells to dispose of metabolic substrates through a newly created vascular supply. Neoangiogenesis was also confirmed in melanoma, where vascular proliferation is associated with increased aggressiveness and poorer prognosis. Furthermore, melanoma cells show the so-called vascular mimicry, consisting in the assumption of endothelial-like features inducing the expression of pro-angiogenic receptors and ligands, which take part in the interplay with extracellular matrix (ECM) components and are potentiated by the ECM remodeling and the barrier molecule junction alterations that characterize the metastatic phase. Although neoangiogenesis was biologically proven and clinically associated with worse outcomes in melanoma patients, in the past anti-angiogenic therapies were employed with poor improvement of the already unsatisfactory results associated with chemotherapic agents. Among the novel therapies of melanoma, immunotherapy has led to previously unexpected outcomes of treatment, yet there is a still strong need for potentiating the results, possibly by new regimens of combination therapies. Molecular models in many cancer types showed mutual influences between im...Continue Reading

References

Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Jan 22, 2005·Current Opinion in Genetics & Development·Peter BalukDonald M McDonald
Mar 23, 2005·Cancer Research·Arati SharmaGavin P Robertson
Jun 30, 2005·Cancer Metastasis Reviews·Marcin KortylewskiHua Yu
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elena RiboldiSilvano Sozzani
Nov 23, 2005·Oncology·Peter Carmeliet
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah Bourbié-VaudainePaul-Henri Roméo
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Betty LiKarin Jooss
Jan 15, 2008·Cancer Immunology, Immunotherapy : CII·Takuya OsadaMichael A Morse
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevJohannes Vieweg
Jul 9, 2008·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Feilim Mac Gabhann, Aleksander S Popel
Jul 18, 2008·Nature Reviews. Cancer·Craig MurdochClaire E Lewis
Jan 24, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Napoleone Ferrara
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Iris HelfrichHellmut G Augustin
Feb 24, 2009·Nature Reviews. Molecular Cell Biology·Hellmut G AugustinKari Alitalo
Jun 2, 2009·Seminars in Cancer Biology·Vanessa Baeriswyl, Gerhard Christofori
May 22, 2010·Seminars in Thrombosis and Hemostasis·Janice A NagyHarold F Dvorak
Oct 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michele Del VecchioAndrea Anichini
Mar 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seth B CoffeltClaire E Lewis
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 11, 2011·Melanoma Research·Amalia VartanianMikhail Lichinitser
Mar 30, 2011·International Journal of Cancer. Journal International Du Cancer·Apostolos C ZiogasAristotle Bamias
Apr 30, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R von MoosUNKNOWN Swiss Group for Clinical Cancer Research (SAKK)
Jul 15, 2011·Nature·Andrea FacciabeneGeorge Coukos
Sep 2, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ahmad A TarhiniJohn M Kirkwood
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin B KimSteven J O'Day
Jan 21, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David R MinorBoris C Bastian
Aug 2, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jahan S KhaliliGregory Lizée
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yuhui HuangMark C Poznansky
Jul 13, 2013·Frontiers in Physiology·Jennifer L Owen, Mansour Mohamadzadeh
May 20, 2014·Cancer Immunology Research·F Stephen HodiDavid McDermott
Jan 21, 2015·The Journal of Experimental Medicine·Thibault VoronMagali Terme
Jan 23, 2016·Nature·Shahin RafiiBi-Sen Ding

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Alexander C ChaconPeter A Prieto
May 10, 2021·Journal of Experimental & Clinical Cancer Research : CR·Simona D'AguannoAntonietta Moramarco

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Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT02158520
NCT01950390
NCT03820986
NCT01495988
NCT04356729
NCT03175432
NCT02681549
NCT03239145

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