Neobenedenia melleni-specific antibodies are associated with protection after continuous exposure in Mozambique tilapia

Journal of Immunology Research
Jennifer M KishimoriJo-Ann C Leong

Abstract

Neobenedenia melleni is a significant monogenean pathogen of fish in aquaculture facilities and public aquaria. Immunity after exposure to live N. melleni is well established, but the mechanisms of immunity remain unclear. In this study, tilapia (Oreochromis mossambicus) were continuously exposed to N. melleni over a four-month period and assessed for immunity as determined by a reduction in the number of parasites dislodged from the experimental animals during freshwater immersion. Specific mucosal and systemic antibody levels were by determined via enzyme-linked immunosorbent assay. At 45 days postexposure (DPE), fish displayed high parasite loads and baseline levels of mucosal antibodies. At 102 and 120 DPE parasite loads were significantly decreased, and antibody levels were significantly increased for mucus and plasma samples. The correlation between immunity (reduction in parasite load) and an increased humoral antibody response suggests a key role of antibody in the immune response. This is the first report of immunity against N. melleni that is associated with specific mucosal or systemic antibodies.

References

Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Joanne L Maki, Harry W Dickerson
Oct 12, 2004·Fish & Shellfish Immunology·Stefaan VervarckeArmand Michoel
Nov 30, 2007·Developmental and Comparative Immunology·Xiguang ZhaoHarry W Dickerson
Jul 25, 2014·Journal of Proteomics·Elisa MaffioliGabriella Tedeschi

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Citations

Nov 7, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Damy Caroline de Melo SouzaEdsandra Campos Chagas
Aug 18, 2020·Fish & Shellfish Immunology·Jana IlgováMartin Kašný

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
protein assay
ABTS

Software Mentioned

JMP

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