PMID: 3746300Oct 1, 1986Paper

Neocortical cholinergic enzyme and receptor activities in the human fetal brain

Journal of Neurochemistry
E K PerryR H Perry

Abstract

In the human fetus, obtained postmortem at estimated gestational ages of 8-22 weeks, biochemical activities of cortical choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were comparable to those of adult brain tissue. In contrast cholinergic receptor binding, including muscarinic M1 and M2 subtypes (measured by displacement of [3H]N-methylscopolamine with, respectively, pirenzepine and carbachol) and [3H]nicotine (putative nicotinic) binding were undetectable before 13-14 weeks and even at 22 weeks were substantially (three- to fourfold) below the respective adult values. Cortical ChAT activity decreased significantly with gestational age whereas binding to the three receptors, including the proportion M1/M2, increased significantly. AChE was present at all ages investigated as the two molecular monomeric (G1) and tetrameric (G4) forms. The proportion of G4, which was much more soluble in fetal compared with adult cortex, increased approximately threefold. Histochemically AChE, although intense in the nucleus of Meynert, was generally confined to subcortical white matter at early fetal developmental periods, appearing later in the cortex localized to nerve fibres and occasional cell bodies. These observations sug...Continue Reading

References

Jan 1, 1986·British Medical Bulletin·E K Perry
Dec 10, 1984·Brain Research·P B ClarkeA Pert
Jan 1, 1984·Journal of Neuroscience Research·H SershenA Lajtha
May 1, 1983·Journal of the Neurological Sciences·J M CandyB E Tomlinson
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Citations

Sep 1, 1987·Human Toxicology·S Wonnacott
Apr 15, 2006·Journal of Neuroscience Research·Iñigo Ruiz de AzúaJoan Sallés
Apr 15, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Caiping MaoZhice Xu
Jan 1, 2004·Toxicology Mechanisms and Methods·Ramesh C Gupta
Sep 26, 1997·The Journal of Comparative Neurology·L C deAzevedoR Lent
Aug 7, 1998·Brain Research. Developmental Brain Research·E Hellström-LindahlA Nordberg
Nov 1, 1992·Neurobiology of Aging·K M ScheggJ H Peacock
Dec 13, 1988·Brain Research·N J Cairns, S Wonnacott
Feb 1, 1989·Early Human Development·B W BrooksbankO S Jørgensen
Mar 10, 2009·Pharmacology & Therapeutics·Jennifer B DwyerFrances M Leslie

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