Neocortical neurodegeneration in young adult Wistar rats prenatally exposed to ethanol

Neurotoxicology and Teratology
Francis Adelade Fakoya, Ezekiel Ademola Caxton-Martins

Abstract

This study was aimed to determine the persistence of neurodegeneration in the cerebral cortex of adult Wistar rats following prenatal ethanol exposure. Timed pregnant rats maintained on standard mouse chow (Ladokun Feeds, Ibadan, Nigeria) and water ad libitum were used for the study. The rats were divided randomly into groups A and B (n-6) and C (n = 4). Group A received a daily ethanol dose of 5.8 g/Kg body weight/day, on the 9th, 10th, 11th, and 12th days of gestation by intragastric intubation, at 16.00 h (PEE) group B was pair-fed with the ethanol dams on isocaloric solution of sucrose for the same duration (PF), while group C received standard chow (C) and water ad libitum. At birth, the pups were weighed and weaned at 30 days of age. Wet brain weights of adult offsprings were determined at 42 days of age. Following whole body perfusion-fixation after anaesthesia, specimens of the neocortex were processed routinely for paraffin embedding and sections of 6 mum thickness stained for neurohistology from each group. Another set of specimens was cryosectioned at -23 degrees C and evaluated for apoptosis by the TUNEL method. The study showed a significantly sustained 44% reduction in brain weight. Neurodegeneration was evident i...Continue Reading

References

Mar 1, 1990·The Journal of Comparative Neurology·M W Miller, G Potempa
Dec 1, 1989·Alcoholism, Clinical and Experimental Research·L A Kotkoskie, S Norton
Dec 15, 1988·The Journal of Comparative Neurology·R W Williams, P Rakic
Nov 3, 1973·Lancet·K L Jones, D W Smith
Dec 1, 1965·J R Microsc Soc·S O Ebbesson, D Tang
Mar 19, 1993·Brain Research. Developmental Brain Research·C R GoodlettJ R West
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·M W Miller
Oct 1, 1996·Journal of Neuroscience Methods·H KondoN Miyazaki
Jun 1, 1997·Journal of Neuroscience Research·P Liesi
Aug 1, 1997·Alcoholism, Clinical and Experimental Research·J L Diaz-GranadosS W Leslie
Oct 6, 1997·Alcoholism, Clinical and Experimental Research·R Hamby-MasonG I Henderson
May 15, 1998·Alcoholism, Clinical and Experimental Research·A P StreissguthP D Sampson
Apr 12, 2000·Neurotoxicology and Teratology·S J KellyA P Streissguth
Jun 6, 2000·Brain Research. Developmental Brain Research·M B HeatonD W Walker
Aug 24, 2000·Seminars in Neonatology : SN·J H Hannigan, D R Armant
Jul 13, 2001·Neurobiology of Disease·K DikranianJ W Olney
Jul 13, 2001·Biochemical Pharmacology·C IkonomidouJ W Olney
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·J W OlneyC Ikonomidou
Mar 8, 2002·Brain Research. Developmental Brain Research·John W OlneyChrysanthy Ikonomidou
Mar 16, 2002·Neurobiology of Disease·John W OlneyKevin A Roth
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·Claire D ColesDavid Freides
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·Sarah N Mattson, Tresa M Roebuck
Jul 11, 2002·Annals of Medicine·John W OlneyChrysanthy Ikonomidou
Jul 19, 2002·The Anatomical Record·Fred L BooksteinAnn P Streissguth
Jan 11, 2003·Neurotoxicology·John W Olney
Jun 28, 2003·Neurotoxicity Research·John W OlneyChrysanthy Ikonomidou

❮ Previous
Next ❯

Citations

Jan 7, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kevser Kusat OlFerruh Yücel
Mar 12, 2016·Neuroscience·Jason H WelchC Fernando Valenzuela

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis