Neocortical slices from adult chronic epileptic rats exhibit discharges of higher voltages and broader spread

Neuroscience
Ruggero SerafiniJeffrey A Loeb

Abstract

Much of the current understanding of epilepsy mechanisms has been built on data recorded with one or a few electrodes from temporal lobe slices of normal young animals stimulated with convulsants. Mechanisms of adult, extratemporal, neocortical chronic epilepsy have not been characterized as much. A more advanced understanding of epilepsy mechanisms can be obtained by recording epileptiform discharges simultaneously from multiple points of an epileptic focus so as to define their sites of initiation and pathways of spreading. Brain slice recordings can characterize epileptic mechanisms in a simpler, more controlled preparation than in vivo. Yet, the intrinsic hyper-excitability of a chronic epileptic focus may not be entirely preserved in slices following the severing of connections in slice preparation. This study utilizes recordings of multiple electrode arrays to characterize which features of epileptic hyper-excitability present in in vivo chronic adult neocortical epileptic foci are preserved in brain slices. After tetanus toxin somatosensory cortex injections, adult rats manifest chronic spontaneous epileptic discharges both in the injection site (primary focus) and in the contralateral side (secondary focus). We prepared...Continue Reading

References

Jun 30, 2000·Cell Biology International·F E DudekJ E Rash
Oct 1, 1991·The European Journal of Neuroscience·K BrenerM J Gutnick
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Siegrun GabrielThomas-Nicolas Lehmann
Oct 22, 2005·Annals of Neurology·Sanjay N RakhadeJeffrey A Loeb
Sep 29, 2009·Clinical EEG and Neuroscience·D T Barkmeier, J A Loeb
Aug 6, 2010·Brain : a Journal of Neurology·Matt SteadGreg A Worrell
Oct 20, 2010·Neuropharmacology·Alfredo Gonzalez-SulserRhonda Dzakpasu
Dec 21, 2010·Seizure : the Journal of the British Epilepsy Association·Dawn S CarterRobert J DeLorenzo
Mar 1, 2011·Seizure : the Journal of the British Epilepsy Association·Bola AdamolekunF A Boop
Apr 5, 2012·Neurobiology of Disease·Daniel T BarkmeierJeffrey A Loeb
Jun 23, 2012·Neuropharmacology·Andrew J Trevelyan, Catherine A Schevon
Sep 14, 2012·Journal of Neurophysiology·Alfredo Gonzalez-SulserRhonda Dzakpasu
Oct 3, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Vicenta Salanova
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas L BeaumontJeffrey A Loeb
Jun 14, 2013·Epilepsy & Behavior : E&B·Anna SerafiniPhilippe Gelisse

❮ Previous
Next ❯

Citations

Feb 4, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ruggero Serafini
Nov 20, 2021·Frontiers in Neuroanatomy·Jun Kyu RheeBradley J Baker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.