Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment

Neurology
M P AmatoNicola De Stefano

Abstract

To assess neocortical changes and their relevance to cognitive impairment in early relapsing-remitting (RR) multiple sclerosis (MS). Conventional MR was acquired in 41 patients with RR MS and 16 demographically matched normal control subjects (NCs). An automated analysis tool was used with conventional T1-weighted MRI to obtain measures of cortical brain volumes normalized for head size. Neuropsychological performance of MS patients was assessed using the Rao Brief Repeatable Battery. Relationship between volumetric MR measures and neuropsychological scores was assessed. Neuropsychological assessment allowed for the identification of 18 cognitively preserved (MS-cp) and 23 cognitively impaired (MS-ci) MS patients. The whole MS sample showed lower values of normalized cortical volumes (NCVs) than did the NC group (p = 0.01). Upon grouping of MS patients according to cognitive performance, NCV values were lower (p = 0.02) in MS-ci patients than in both MS-cp patients and NCs. Moreover, there were positive correlations between NCV values and measures of verbal memory (r = 0.51, p = 0.02), verbal fluency (r = 0.51, p = 0.01), and attention/concentration (r = 0.65, p < 0.001) in MS-ci patients. Furthermore, NCV values were decreased...Continue Reading

Citations

Mar 15, 2005·Der Nervenarzt·C EngelU K Zettl
Apr 13, 2006·Journal of Neurology·Doreen SchulzJürgen H Faiss
Nov 10, 2006·Journal of Neurology·Bertrand AudoinDavid H Miller
Mar 16, 2007·Journal of Neurology·Massimiliano CalabresePaolo Gallo
Feb 16, 2006·Journal of Neurology·Pasquale Calabrese
May 16, 2007·Journal of Neurology·Michael LanzHelmut Hildebrandt
Apr 9, 2009·Journal of Neurology·Blandine GrassiotGilles Defer
Jul 14, 2012·Brain Structure & Function·Asaf AchironAnat Achiron
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M Filippi, M A Rocca
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F RinaldiP Gallo
May 8, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·O SantiagoTx Arbizu
Jan 1, 2014·Clinical Neurology and Neurosurgery·V V Brinar, B Barun
May 17, 2005·Physical Medicine and Rehabilitation Clinics of North America·Jack H Simon
Aug 16, 2008·Lancet Neurology·Jeroen J G Geurts, Frederik Barkhof
Apr 21, 2007·Journal of the International Neuropsychological Society : JINS·Brett A ParmenterDavid W Shucard
Jul 9, 2010·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictDavid J Schretlen
Mar 14, 2012·Journal of the International Neuropsychological Society : JINS·Thomas J CoveyRalph H B Benedict
Oct 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco MoriDiego Centonze
Jul 14, 2010·Nature Reviews. Neurology·Massimiliano CalabresePaolo Gallo
May 11, 2011·Nature Reviews. Neurology·Ralph H B Benedict, Robert Zivadinov
Mar 9, 2012·BMC Neurology·Dana HorakovaOndrej Dolezal
Mar 9, 2012·BMC Neurology·Bogdan F Gh Popescu, Claudia F Lucchinetti
Nov 13, 2012·PloS One·Francesca RossiNicola De Stefano
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Charlotte E TeunissenHenk J Blom
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Rohit BakshiJerry S Wolinsky
May 6, 2014·Current Opinion in Neurology·Massimo FilippiMaria A Rocca
Sep 17, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Laëtitia DebernardDeborah F Mason
Apr 13, 2006·Journal of Neurology·Maria Pia AmatoMaria Trojano
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonio Giorgio, Nicola De Stefano
Jan 22, 2014·CNS Drugs·Nicola De StefanoBernd C Kieseier
Feb 9, 2012·Annual Review of Pathology·Bogdan F Gh Popescu, Claudia F Lucchinetti
Sep 13, 2014·Clinical Neurology and Neurosurgery·Rana AssouadBruno Stankoff
Dec 3, 2014·Clinical Neurology and Neurosurgery·Murat YildizStefan Borgwardt
Feb 12, 2011·AJNR. American Journal of Neuroradiology·A MikeC R G Guttmann
May 15, 2007·Current Opinion in Neurology·Stefanie HoffmannD Yves von Cramon
May 3, 2008·Current Opinion in Neurology·Christine StadelmannWolfgang Brück

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.