Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior

Cell Death & Disease
Dong SunWen-Cheng Xiong

Abstract

Adult neurogenesis in hippocampal dentate gyrus (DG) is a complex, but precisely controlled process. Dysregulation of this event contributes to multiple neurological disorders, including major depression. Thus, it is of considerable interest to investigate how adult hippocampal neurogenesis is regulated. Here, we present evidence for neogenin, a multifunctional transmembrane receptor, to regulate adult mouse hippocampal neurogenesis. Loss of neogenin in adult neural stem cells (NSCs) or neural progenitor cells (NPCs) impaired NSCs/NPCs proliferation and neurogenesis, whereas increased their astrocytic differentiation. Mechanistic studies revealed a role for neogenin to positively regulate Gli1, a crucial downstream transcriptional factor of sonic hedgehog, and expression of Gli1 into neogenin depleted NSCs/NPCs restores their proliferation. Further morphological and functional studies showed additional abnormities, including reduced dendritic branches and spines, and impaired glutamatergic neuro-transmission, in neogenin-depleted new-born DG neurons; and mice with depletion of neogenin in NSCs/NPCs exhibited depressive-like behavior. These results thus demonstrate unrecognized functions of neogenin in adult hippocampal NSCs/NPC...Continue Reading

References

Feb 16, 1996·Science·C LoisA Alvarez-Buylla
Apr 12, 2002·Brain Research. Developmental Brain Research·N L Hayes, R S Nowakowski
Dec 7, 2002·Nature Neuroscience·Karen LaiDavid V Schaffer
Apr 15, 2004·Developmental Biology·David J MawdsleyJoan K Heath
Jul 20, 2004·Nature Cell Biology·Srikanth RajagopalanStephen M Strittmatter
Jul 20, 2004·Nature Cell Biology·Eiji MatsunagaAlain Chédotal
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Nov 3, 2004·The Journal of Cell Biology·Jong-Sun KangRobert S Krauss
Dec 18, 2004·Development·Verónica PalmaAriel Ruiz i Altaba
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanjay S P MagaviJeffrey D Macklis
Feb 24, 2006·Nature Reviews. Neuroscience·Pierre-Marie LledoMatthew S Grubb
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eiji MatsunagaAlain Chédotal
Nov 23, 2006·Trends in Neurosciences·Shaoyu GeHongjun Song
Apr 26, 2007·Genesis : the Journal of Genetics and Development·Kristen B CasperKen D McCarthy
Jul 3, 2007·Gene Expression Patterns : GEP·Daniel P FitzgeraldHelen M Cooper
Feb 22, 2008·American Journal of Physiology. Cell Physiology·Robin Kuns-HashimotoPeter Rotwein
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joshua J BreunigTerrence Town
Mar 17, 2009·Nature Neuroscience·Li-Chun ChengFiona Doetsch
Jul 1, 2009·The Journal of Biological Chemistry·An-Sheng ZhangCaroline A Enns
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Itaru ImayoshiRyoichiro Kageyama
May 18, 2010·Current Opinion in Neurobiology·Yangling MuFred H Gage
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Federico MassaStéphane H R Oliet
Jan 26, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mingi HongRobert S Krauss
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yun LiLuis F Parada
Jun 19, 2013·International Journal of Cancer. Journal International Du Cancer·Luis A MillaVerónica Palma
Aug 15, 2014·Stem Cell Research·Yu-Rim KwonJong-Sun Kang

❮ Previous
Next ❯

Citations

Jan 28, 2020·Biotechnology and Applied Biochemistry·Xinfei MaJinao Duan
Jul 25, 2019·Journal of Molecular Cell Biology·Sen LinWen-Cheng Xiong
Jan 18, 2019·Molecular Psychiatry·Kyungchul NohSung Joong Lee
Aug 31, 2020·Neuroscience Insights·Toke Jost Isaksen, Toshihide Yamashita
Aug 28, 2020·The Journal of Clinical Investigation·Ling-Ling YaoWen-Cheng Xiong
Apr 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dong SunWen-Cheng Xiong
Jul 11, 2021·Neuroscience·In-Young ChoiKyung-Ok Cho
Jul 3, 2018·Neurobiology of Learning and Memory·Ana Raquel Pereira-CaixetaGrace S Pereira
Aug 22, 2021·Archives of Biochemistry and Biophysics·Tongyin ZhangNa Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

ImageJ
Brdu
Image J

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.