Neogenin in Amygdala for Neuronal Activity and Information Processing

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Xiang-Dong SunLin Mei

Abstract

Fear learning and memory are vital for livings to survive, dysfunctions in which have been implicated in various neuropsychiatric disorders. Appropriate neuronal activation in amygdala is critical for fear memory. However, the underlying regulatory mechanisms are not well understood. Here we report that Neogenin, a DCC (deleted in colorectal cancer) family receptor, which plays important roles in axon navigation and adult neurogenesis, is enriched in excitatory neurons in BLA (Basolateral amygdala). Fear memory is impaired in male Neogenin mutant mice. The number of cFos+ neurons in response to tone-cued fear training was reduced in mutant mice, indicating aberrant neuronal activation in the absence of Neogenin. Electrophysiological studies show that Neogenin mutation reduced the cortical afferent input to BLA pyramidal neurons and compromised both induction and maintenance of Long-Term Potentiation evoked by stimulating cortical afferent, suggesting a role of Neogenin in synaptic plasticity. Concomitantly, there was a reduction in spine density and in frequency of miniature excitatory postsynaptic currents (mEPSCs), but not miniature inhibitory postsynaptic currents, suggesting a role of Neogenin in forming excitatory synapses...Continue Reading

Citations

Mar 3, 2020·Frontiers in Neuroscience·Feng GaoXiang-Dong Sun
Sep 19, 2020·Cell & Bioscience·Wen-Bing ChenBing-Xing Pan
Nov 12, 2019·Frontiers in Psychology·Huan-Huan ZhangYan-Xue Xue
Apr 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dong SunWen-Cheng Xiong

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