Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation.

Developmental Cell
Zheng ZhouWen-Cheng Xiong

Abstract

Neogenin has been identified as a receptor for the neuronal axon guidance cues netrins and RGMs (repulsive guidance molecules). Here we provide evidence for neogenin in regulating endochondral bone development and BMP (bone morphogenetic protein) signaling. Neogenin-deficient mice were impaired in digit/limb development and endochondral ossification. BMP2 induction of Smad1/5/8 phosphorylation and Runx2 expression, but not noncanonical p38 MAPK activation, was reduced in chondrocytes from neogenin mutant mice. BMP receptor association with membrane microdomains, which is necessary for BMP signaling to Smad, but not p38 MAPK, was diminished in neogenin-deficient chondrocytes. Furthermore, RGMs appear to mediate neogenin interaction with BMP receptors in chondrocytes. Taken together, our results indicate that neogenin promotes chondrogenesis in vitro and in vivo, revealing an unexpected mechanism underlying neogenin regulation of BMP signaling.

References

Feb 10, 1995·Cell·A ErlebacherR Derynck
Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
May 18, 1999·Developmental Biology·S PathiA Vortkamp
Apr 24, 2002·Developmental Cell·Gerard Karsenty, Erwin F Wagner
Nov 6, 2002·Biological Research·Tony MageeIngela Parmryd
May 16, 2003·Nature·Henry M Kronenberg
Aug 20, 2003·The Journal of Bone and Joint Surgery. American Volume·Sylke HasselPetra Knaus
Jul 20, 2004·Nature Cell Biology·Srikanth RajagopalanStephen M Strittmatter
Sep 8, 2004·Journal of Cellular Biochemistry·Byeong S Yoon, Karen M Lyons
Oct 21, 2004·Nature Neuroscience·Xiu-Rong RenWen-Cheng Xiong
Jan 27, 2005·The Journal of Biological Chemistry·Tarek A SamadClifford J Woolf
Mar 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·Byeong S YoonKaren M Lyons
Jun 25, 2005·The Journal of Biological Chemistry·Jodie L BabittHerbert Y Lin
Aug 17, 2005·The Journal of Biological Chemistry·An-Sheng ZhangCaroline A Enns
Oct 11, 2005·Journal of Cellular Biochemistry·Mary B GoldringKosei Ijiri
Apr 11, 2006·Nature Genetics·Jodie L BabittHerbert Y Lin
May 5, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dan ZhuLin Mei
Jul 13, 2006·Annals of the New York Academy of Sciences·Henry M Kronenberg
Aug 3, 2006·Current Medical Research and Opinion·P ten Dijke
Aug 23, 2006·Molecular and Cellular Biology·Anke HartungPetra Knaus
Nov 23, 2006·Current Topics in Developmental Biology·Robert Pogue, Karen Lyons
Dec 2, 2006·The International Journal of Biochemistry & Cell Biology·Nicole H Wilson, Brian Key
Dec 16, 2006·Current Opinion in Neurobiology·Toshihide YamashitaKatsuhiko Hata
Jan 6, 2007·The International Journal of Biochemistry & Cell Biology·Stacey J ColeHelen M Cooper
Jul 31, 2007·The International Journal of Biochemistry & Cell Biology·E J MackieM Mirams
Jan 30, 2008·Current Protocols in Cell Biology·T OkamotoM P Lisanti
Apr 10, 2008·Journal of Cell Science·Mo ChenRegis J O'Keefe
Apr 25, 2008·Development·Kinglun Kingston MakYingzi Yang
Aug 30, 2008·Biochemical and Biophysical Research Communications·Jeffrey W Wertz, Philip M Bauer
Sep 5, 2008·Annual Review of Genomics and Human Genetics·Gerard Karsenty
Mar 3, 2009·Nature Genetics·Delphine MeynardMarie-Paule Roth
Apr 29, 2009·The Journal of Cell Biology·Patrick LajoieIvan R Nabi
Jul 1, 2009·The Journal of Biological Chemistry·An-Sheng ZhangCaroline A Enns

❮ Previous
Next ❯

Citations

Jul 4, 2012·Cellular and Molecular Life Sciences : CMLS·SongTing ShiPeter ten Dijke
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yoko HosakaHiroshi Kawaguchi
Aug 16, 2012·The Journal of Biological Chemistry·Caroline A EnnsAn-Sheng Zhang
Jun 8, 2013·Science·Christian H BellChristian Siebold
Jan 5, 2012·Molecular and Cellular Biology·Grace J Lah, Brian Key
Dec 29, 2012·Fibrogenesis & Tissue Repair·Thavaneetharajah PretheebanFabio M Rossi
Mar 14, 2012·PloS One·Klemens KönigValbona Mirakaj
Dec 7, 2013·PloS One·Conor O'LearyHelen M Cooper
Feb 3, 2012·International Journal of Biological Sciences·Guiqian ChenYi-Ping Li
Nov 23, 2011·The Journal of Cell Biology·Lei WenWen-Cheng Xiong
Mar 20, 2013·The Journal of Cell Biology·Wen-Fang XiaWen-Cheng Xiong
Jun 20, 2012·FEBS Letters·Jie CaiPeter ten Dijke
Apr 6, 2013·Journal of Cellular Physiology·Dimitrios AgasMarja M Hurley
Dec 15, 2015·Developmental Cell·Susan van ErpR Jeroen Pasterkamp
Oct 18, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Erika Cristina JorgeSusanne Dietrich
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Alexander Weiss, Liliana Attisano
Jun 7, 2013·Molecular Reproduction and Development·Chenxi Tian, Jun Liu
Jan 26, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mingi HongRobert S Krauss
Aug 14, 2012·Developmental Neurobiology·Nigel KeeHelen M Cooper
Dec 10, 2015·BioMed Research International·R V DeevA A Isaev
May 28, 2013·Biochimica Et Biophysica Acta·María González-NúñezJosé M López-Novoa
May 6, 2015·Nature Structural & Molecular Biology·Eleanor G HealeyChristian Siebold
Feb 22, 2012·Developmental Cell·Nardos G TassewPhilippe P Monnier
Aug 16, 2014·Cell Reports·Nardos G TassewPhilippe P Monnier
Nov 27, 2014·Cellular and Molecular Life Sciences : CMLS·Zohreh Khavandgar, Monzur Murshed
Nov 20, 2016·Cold Spring Harbor Perspectives in Biology·Ying E Zhang
Jun 18, 2017·Biochemical and Biophysical Research Communications·Namgue HongJae Ho Lee
May 5, 2016·Development·Joseph Wai Keung KamJean-François Cloutier
Jun 27, 2018·Journal of the Endocrine Society·J Douglas CoffinMarja Marie Hurley
Jan 16, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bo WangWen-Cheng Xiong
Dec 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Valbona MirakajPeter Rosenberger
Jul 25, 2019·Journal of Molecular Cell Biology·Sen LinWen-Cheng Xiong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.