Neointimal hyperplasia in allogeneic and autologous venous grafts is not different in nature

Histochemistry and Cell Biology
Albert BuschUdo Lorenz

Abstract

Neointimal hyperplasia, transplant rejection and thus immunogenicity of allografts are possible reasons for poorer patency rates in cryopreserved venous allografts for peripheral bypass surgery in comparison with autologous venous grafts. To expand the limited knowledge from human allografts, we histologically investigated allogeneic and autologous venous grafts in arterial location. Specimens of allogeneic and autologous venous graft stenosis, harvested 6 months after bypass implantation, were immunohistochemically characterized. Examination of the lesions showed a uniform morphological pattern. A continuous endothelial layer, tissue fibrosis and a thickened neointima with monocytes and dedifferentiated vascular smooth muscle cells were seen in both conduits with very low cell turnover and the absence of acute and chronic inflammation. Neoangiogenesis with CD34-positive endothelium was abundant in the vessel media. The morphological patterns of allogeneic and autologous neointima formation are similar. Consequently, neointimal hyperplasia in venous grafts may reflect a uniform physiological host response of non-immunological factors with the reasons for poorer clinical outcome of cryopreserved allografts yet to be elucidated.

References

Feb 1, 1989·Journal of Vascular Surgery·T R KohlerA W Clowes
Nov 1, 1994·European Journal of Vascular Surgery·G Faggioli, J J Ricotta
May 1, 1997·Annals of Vascular Surgery·G LesècheB Andréassian
Jul 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A D GiannoukasA N Nicolaides
Apr 18, 1998·Journal of Vascular Surgery·J P Carpenter, J E Tomaszewski
May 11, 2000·Journal of Vascular Surgery·T R JohnsonJ P Carpenter
Sep 16, 2000·Journal of the American College of Surgeons·A WesterbandJ L Mills
Mar 10, 2001·Journal of Vascular Surgery·L HarrisJ J Ricotta
Oct 9, 2002·Journal of Vascular Surgery·Lisheng ZhangNeil J Freedman
Jul 5, 2003·Journal of Vascular Surgery·Alik FarberPhilip M Levin
Aug 24, 2005·Antioxidants & Redox Signaling·Andreas Schober, Christian Weber
Sep 21, 2005·Circulation·Rohit KhuranaIan C Zachary
Oct 20, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marc P PusztaszeriFred T Bosman
Mar 8, 2006·Immunology and Cell Biology·Amit K MitraDevendra K Agrawal
Sep 5, 2006·Journal of Vascular Surgery·Peter J FahnerDink A Legemate
Mar 30, 2007·Journal of Vascular Surgery·Paul KreienbergR Clement Darling
Dec 17, 2009·Seminars in Vascular Surgery·Michael S Conte
Sep 1, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M G Davies, P-O Hagen
Feb 11, 2012·Current Opinion in Pharmacology·Nilima Shukla, Jamie Y Jeremy
Mar 27, 2012·Current Opinion in Pharmacology·Dominik WiedemannThomas Schachner
Apr 3, 2012·Cardiovascular Research·Patrick LacolleyJean-Baptiste Michel
Jun 2, 2012·Expert Review of Cardiovascular Therapy·Michael J CollinsAlan Dardik
Jan 1, 2013·Histochemistry and Cell Biology·Agnieszka MalinskaMichal Nowicki
Jan 29, 2013·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M BolL Leybaert
Feb 12, 2013·Journal of Vascular Surgery·Neal R BarshesMichael Belkin

❮ Previous
Next ❯

Citations

Feb 18, 2016·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
May 10, 2017·Histochemistry and Cell Biology·Albert BuschLars Maegdefessel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.