Neointimal thickening after severe coronary artery injury is limited by a short-term administration of a factor Xa inhibitor. Results in a porcine model

Circulation
R S SchwartzR G Johnson

Abstract

Fibrin- and platelet-rich thrombus formations occur as the initial event after percutaneous transluminal coronary angioplasty. We therefore tested the hypothesis that short-term administration of the recombinant tick anticoagulant peptide (rTAP), a factor Xa inhibitor, would reduce the thickness of neointima at 28 days after injury in a porcine coronary balloon angioplasty model. Continuous intravenous infusion of rTAP (average dose, 194 micrograms . kg-1 . min-1) or placebo (vehicle only) was given to the study pigs for 60 hours. The goal of anticoagulation was to maintain the activated clotting time at 200 seconds. A central venous catheter was inserted 2 days before the procedure. On the day of coronary injury, the animals were administered boluses of rTAP (6.5 mg) and then underwent injury with an oversized metallic coil by standard methods in the right, circumflex, or left anterior descending coronary artery. No significant difference in vascular injury between rTAP and vehicle control was observed after euthanasia at 28 days. Significantly less neointimal thickening occurred in the rTAP-treated animals (thickness, mean +/-SD: 0.30 +/-0.08 mm) compared with the control (0.48 +/- 0.12 mm, P< .001). The specific factor Xa in...Continue Reading

References

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Apr 11, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
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Jan 1, 1993·Mayo Clinic Proceedings·R S SchwartzD R Holmes

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Citations

Jan 13, 2011·Thrombosis and Haemostasis·Alexander G G Turpie, Charles Esmon
Sep 6, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Feroze NazneenMichael Thompson
Mar 2, 2006·Toxicologic Pathology·Arturo G Touchard, Robert S Schwartz
Oct 28, 2005·Cardiovascular and Interventional Radiology·T RandJ Lammer
Jul 10, 2001·American Journal of Physiology. Cell Physiology·O P Blanc-BrudeG J Laurent
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·D R AbendscheinJ St Pierre
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Yoriyasu SuzukiFumiaki Ikeno
Mar 21, 2002·Journal of Cardiovascular Pharmacology·Yasuharu MatsumotoAkira Takeshita
Aug 22, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·M OberhoffK R Karsch
Aug 11, 2020·Current Problems in Surgery·Morgan P McMonagle
Dec 29, 2000·Journal of the American College of Cardiology·M RoquéJ J Badimon
Jul 28, 2009·Insect Biochemistry and Molecular Biology·María Angeles Corral-RodríguezPablo Fuentes-Prior

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