PMID: 6409353Jun 6, 1983Paper

Neonatal 6-hydroxydopa alters conspecific odor investigation by male rats

Brain Research
C A Cornwell-Jones, H R Bollers

Abstract

Odor-guided behavior was examined in male rats injected at birth and 48 h later with either the catecholaminergic neurotoxin 6-hydroxydopamine (60 micrograms/g, i.p.) or vehicle. In odor preference tests administered 8 or 74 days postnatally, drug-treated animals avoided novel odors which were neutral for controls and showed reduced preference for conspecific nest odors. In emergence tests administered 73-75 days postnatally, odors from an anesthetized female reduced approach latency and increased investigation of familiar conspecific odors for control but not drug-treated males. Neonatal drug treatment decreased adult olfactory cortex norepinephrine (NE) levels by 50%, but did not significantly influence either cardiac NE or olfactory cortex dopamine. The results imply that brain NE facilitates attraction to familiar conspecific odors.

References

Sep 1, 1978·Physiology & Behavior·S T MasonH C Fibiger
May 1, 1978·Pharmacology, Biochemistry, and Behavior·D M Jacobowitz, J S Richardson
Nov 1, 1977·Behavioral Biology·S K Sobrian, C Cornwell-Jones
May 1, 1976·Pharmacology, Biochemistry, and Behavior·J H McLeanJ G May
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·J H McLeanJ G May
Feb 10, 1980·Brain Research·C A Cornwell-Jones, E M Marasco
Jun 1, 1965·Journal of Comparative and Physiological Psychology·W J CARRM L DISSINGER

❮ Previous
Next ❯

Citations

Jan 1, 1989·Neurochemistry International·J M Evans, G Cohen
Jun 1, 1987·Brain Research Bulletin·H PerezC R Almli
Nov 1, 1990·Brain Research Bulletin·C A Cornwell-JonesJ L McGaugh
Jul 1, 1988·Behavioral and Neural Biology·C A Cornwell-Jones
Mar 4, 1996·Brain Research·C A CornwellJ L McGaugh
Mar 1, 1989·Archives of Environmental Health·H E AmandusT B Richards

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.