PMID: 2504438Jul 31, 1989Paper

Neonatal 6-hydroxydopa, but not DSP-4, elevates brainstem monoamines and impairs inhibitory avoidance learning in developing rats

Brain Research
C A Cornwell-JonesJ L McGaugh

Abstract

The involvement of brain monoamines in learning and memory in developing rats was studied by comparing the effects of 3 different noradrenergic neurotoxin treatments. Two experimental groups of male Sprague-Dawley rat pups were injected systemically with 50 micrograms/g of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) either on the day of birth or on postnatal days 17-18. Rats in the third experimental group were injected systemically with 60 micrograms/g of 6-hydroxydopa (6-OHDOPA) on postnatal days 0 and 2. Control littermates received vehicle. The animals were trained on an inhibitory avoidance task on postnatal days 27-29 and tested for retention 24 h later. The drug treatments produced comparable depletion of norepinephrine in the hippocampus and frontal cortex. 6-OHDOPA, but neither DSP-4 treatment, significantly elevated brainstem concentrations of norepinephrine and serotonin. In addition, 6-OHDOPA, but not DSP-4, significantly impaired retention of the inhibitory avoidance task. The impairment did not reflect insensitivity to the footshock used in training: both neonatal drug treatments tended to lower, not raise, footshock thresholds, as measured by a flinch test. High affinity choline uptake was not affected b...Continue Reading

References

May 1, 1975·Journal of Neurochemistry·P T Carroll, G G Buterbaugh
Jul 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·B A Pappas, S K Sobrian
Jul 19, 1973·Psychopharmacologia·B A Campbell, P D Mabry
Jan 1, 1983·Annual Review of Psychology·J L McGaugh

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Citations

Jul 19, 2000·Journal of Neuroscience Research·G J YohrlingK E Vrana
Jan 1, 1992·Archives of Toxicology·V L CastroJ Palermo-Neto
Aug 11, 1992·Physiology & Behavior·C A Cornwell-JonesK Kinnard
Nov 1, 1990·Brain Research Bulletin·C A Cornwell-JonesJ L McGaugh
Jun 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E S BachmanC F Hohmann
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·M B PassaniP Blandina
Jul 3, 1999·Neuroscience·M F WuJ M Siegel
Feb 26, 2008·Behavioural Brain Research·Behrooz Khakpour-TaleghaniFereshteh Motamedi

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