Neonatal adenoviral infection: a seventeen year experience and review of the literature

The Journal of Pediatrics
Andrea RonchiPablo J Sánchez

Abstract

To describe the clinical manifestations and short-term outcomes of adenoviral infections in neonates and review all published cases to better determine impact and treatment outcomes. Retrospective cohort study of all neonates hospitalized at Children's Medical Center (CMC) and Parkland Memorial Hospital (PMH), Dallas, TX with laboratory-confirmed adenoviral infection from January 1,1995-December 31, 2012. Neonates were identified by review of the CMC Virology Laboratory's prospective database of all positive adenovirus tests performed in the inpatient and ambulatory settings, and at PMH, of a prospective neonatal database that included all neonatal intensive care unit admissions. Patients also were identified by discharge International Classification of Disease, 9th edition codes for adenoviral infection. The medical records were reviewed, and a review of the English literature was performed. During 17 years, 26 neonates had adenoviral infection (25, CMC; 1, PMH). The principle reasons for hospitalization were respiratory signs (88%) and temperature instability (65%). Five (19%) had disseminated disease and 4 (80%) of these infants died. Ribavirin or cidofovir treatment, as well as immune globulin intravenous, did not improve o...Continue Reading

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Citations

Jul 21, 2015·Infectious Disease Clinics of North America·Christian Renaud, Christopher J Harrison
Jul 9, 2016·Acta Paediatrica·Raakel LuotoTerho Heikkinen
May 19, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·J B CeroneA Rios
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Mar 15, 2016·The Pediatric Infectious Disease Journal·Eunkyung SongPreeti Jaggi
Aug 31, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Jessica E ShuiLisa Saiman
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Aug 28, 2020·Microorganisms·Bratati Saha, Robin J Parks
Jun 19, 2015·Clinical Microbiology Reviews·Jose L SanchezCharlotte A Gaydos

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