PMID: 6111085Dec 1, 1980Paper

Neonatal administration of Met-enkephalin facilitates maze performance of adult rats

Pharmacology, Biochemistry, and Behavior
A J KastinD H Coy

Abstract

Newborn rats were injected SC during the first week of life with 80 microgram/kg Met-enkephalin, DSIP, MIF-I, or diluent. When tested 3 months later in a 12-choice maze for a reward of food, hungry rats injected neonatally with Met-enkephalin were found to run the maze faster and with fewer errors than the controls. DSIP and MIF-I did not improve performance in the maze, indicating some specificity to the findings. Tyrosine hydroxylase and choline acetyltransferase activity in several parts of the brain were not significantly different among the groups. Radioimmunoassay of brain parts from a small number of adult rats indicated slightly more DSIP-like material in the thalamus and striatum of females injected neonatally with DSIP as compared with those injected with diluent. The results extend our previous observations of the persistence of central effects of peripherally injected Met-enkephalin from several minutes to three months when administration occurs early in life. The findings further suggest an effect of peptides on the organization of the developing brain.

References

Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·L O Stratton, A J Kastin
Jul 30, 1979·Life Sciences·A J KastinD H Coy
May 15, 1976·Life Sciences·H van der Helm-Hylkema, D de Wied
Nov 1, 1978·Brain Research Bulletin·A J KastinD H Coy
Dec 1, 1979·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·L O StrattonA J Kastin
Jan 1, 1977·Physiology & Behavior·B E BeckwithA J Kastin
Dec 1, 1976·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
Oct 1, 1972·Journal of Neurochemistry·V Glover, D P Green

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Citations

Aug 1, 1984·Physiology & Behavior·G E HandelmannC J Helke
Sep 1, 1984·Physiology & Behavior·A J KastinA J Fischman
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·C de Cabo de la VegaM Paz Viveros
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·I S ZagonE Zagon
Nov 1, 1982·Peptides·G StickrodW P Smotherman
Dec 1, 1981·Brain Research Bulletin·R L MoldowC A Sandman
Dec 1, 1981·Brain Research Bulletin·A J KastinD H Coy
Oct 1, 2012·Journal of Developmental Origins of Health and Disease·Z Y OngB S Muhlhausler
Dec 1, 1981·The Journal of Legal Medicine·J Harrison
Jan 1, 1990·Annals of the New York Academy of Sciences·A J KastinJ E Zadina
Mar 22, 1996·Annals of the New York Academy of Sciences·A J KastinW A Banks
Jan 1, 1981·Peptides·G A OlsonD H Coy

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