Neonatal administration of monosodium glutamate prevents the development of ethanol- but not psychostimulant-induced sensitization: a putative role of the arcuate nucleus

The European Journal of Neuroscience
Marta MiquelCarlos M G Aragon

Abstract

Lesions of the arcuate nucleus by monosodium glutamate, goldthioglucose and oestradiol valerate treatments are known to prevent the acute stimulating effect of ethanol in mice. On the basis of these results, the current study analysed whether a lesion of the arcuate nucleus by monosodium glutamate was able to block ethanol-induced locomotor sensitization. To produce the arcuate nucleus lesions, pups were injected with saline or monosodium glutamate (4 mg/g body weight) subcutaneously on 5 alternate days, starting on postnatal day one. Sensitization treatments began 10 weeks after the initial lesions. Sensitization training consisted of six trials on alternate days, in which groups of mice were treated with ethanol (2 g/kg) or saline, and then tested in an open-field for the induction of locomotor activity. The present study demonstrated that animals with monosodium glutamate-induced lesions did not develop locomotor sensitization to ethanol. Different groups of mice were used to assay blood ethanol levels and to evaluate the effect of arcuate nucleus lesions on psychostimulant-induced locomotor sensitization. Sensitization to cocaine or amphetamine was spared in monosodium glutamate-pre-treated animals, although the lesion of a...Continue Reading

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Citations

Dec 25, 2007·Psychopharmacology·Rebekah A StevensonClyde W Hodge
Jun 29, 2004·Behavioural Brain Research·Carla Sanchis-SeguraCarlos M G Aragon
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Raúl Pastor, Carlos M G Aragon
Sep 26, 2013·International Journal of Molecular Sciences·Gabor HorvathPeter Kiss
Nov 21, 2013·Pharmacology, Biochemistry, and Behavior·Juan Carlos LedesmaCarlos M G Aragon
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Raúl PastorCarlos M G Aragon
Sep 13, 2005·Alcoholism, Clinical and Experimental Research·Carla Sanchis-SeguraMichael S Cowen
Apr 25, 2009·Alcoholism, Clinical and Experimental Research·Amanda L Sharpe, Malcolm J Low
Oct 22, 2011·Alcoholism, Clinical and Experimental Research·Raúl PastorCarlos M G Aragon
Feb 8, 2005·Neuroscience Letters·Carla Sanchis-SeguraCarlos M G Aragon
Oct 21, 2015·Psychopharmacology·Dolores Vazquez-SanromanMarta Miquel
Aug 10, 2011·Neuroscience and Biobehavioral Reviews·Mercè CorreaElio Acquas
Mar 29, 2018·PloS One·M Carmen Blanco-GandíaMarta Rodríguez-Arias

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