Neonatal adrenoleukodystrophy presenting with seizure at birth: a case report and review of the literature

Pediatric Neurology
Ying-Chao ChangFang-Chih Hung

Abstract

Neonatal seizures are critical conditions because they are usually related to significant illnesses that require a specific therapy. Antepartum and peripartum seizures are very rare, and represent signs of prenatal-onset neurologic dysfunction. A review of the literature revealed that the main etiologies include severe brain malformations, multiple anomalies, and metabolic encephalopathy. A high incidence of early fatality and serious neurologic sequelae were noted. To our knowledge, this is the first case report of neonatal adrenoleukodystrophy presenting with seizure at birth. These very-early-onset seizures may require unique diagnostic and therapeutic considerations, in contrast with the later onset of seizures in neonates.

References

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Citations

Oct 4, 2011·Journal of Clinical Imaging Science·R Nuri Sener, Mehmet H Atalar
Sep 1, 2009·Journal of Clinical Research in Pediatric Endocrinology·John W Honour
Nov 16, 2011·Magnetic Resonance Imaging Clinics of North America·Zoltán Patay
Mar 11, 2017·Internal and Emergency Medicine·Josef Finsterer, Claudia Stöllberger

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