Abstract
Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens presented on foetal platelets cause their immune destruction. Whether human leucocyte antigen (HLA) antibodies can cause NAIT is controversial. Here, a patient was described who suffered from a NAIT caused by an HLA-B27 antibody. Sera from the mother and the newborn were tested for human platelet antigen antibodies and HLA antibodies by monoclonal antibody-specific immobilization of platelet antigens (MAIPA) assay, solid phase-linked immunosorbent assay (ELISA), lymphocytotoxicity assay (LCT) and flow cytometric analysis. No antibodies against cluster designation (CD)109 and platelet glycoproteins of the father were found in patient's and mother's serum. However, HLA ELISA was used to identify HLA antibody in both sera. The antibody was specified as HLA-B27 antibody. Typing results showed that the father descended HLA-B27 antigen on patient and his brother. The mother was HLA-B27 negative. It is most conceivable that the previous pregnancy of the mother induced the production of anti-HLA-B27 antibody, which crossed the placenta and subsequently caused an NAIT in the case presented.
References
Jan 1, 1992·Acta Haematologica·M P ChowT D Lee
Jul 1, 1991·British Journal of Haematology·C KaplanC Mueller-Eckhardt
Aug 1, 1990·Obstetrical & Gynecological Survey·E Taaning, L Skibsted
Feb 18, 1989·Lancet·C Mueller-EckhardtS Santoso
Jan 1, 1986·Current Studies in Hematology and Blood Transfusion·M S SternbachR M Guévin
Jul 1, 1995·British Journal of Haematology·S PanzerS Walchshofer
Nov 1, 1994·Transfusion·L R MarshallA L Barr
Mar 1, 1996·Tissue Antigens·K E KingT S Kickler
Jul 3, 1997·The New England Journal of Medicine·J B BusselJ G McFarland
Aug 1, 1997·Transfusion·J O BordinC P Hayward
Jun 17, 1998·Journal of Pediatric Hematology/oncology·M L del RosarioK J Kao
Jul 29, 2000·Transfusion Medicine Reviews·E Taaning
Sep 21, 2000·British Journal of Haematology·J E BerryW H Ouwehand
Dec 21, 2000·British Journal of Haematology·M F Murphy, L M Williamson
Jan 5, 2002·Pediatric Hematology and Oncology·M SasakiH Ikeda
Feb 28, 2002·Blood·Andre C SchuhWillem H Ouwehand
Jun 26, 2003·Transfusion·Satoshi SaitoHirofumi Fukushima
May 22, 2004·Acta Haematologica·P MoncharmontD Rigal
May 26, 2004·Transfusion·Julie RousseauMichèle David
Citations
Feb 18, 2011·PloS One·JoonHo LeeChong Jai Kim
Nov 9, 2015·Journal of Reproductive Immunology·J DahlH Tiller
Oct 14, 2008·Transfusion Medicine Reviews·Donald M ArnoldJohn G Kelton
Dec 4, 2008·Advances in Pediatrics·Alice Chang HoftmanE Richard Stiehm
Sep 11, 2007·Seminars in Perinatology·YanYun Wu, Gary Stack
Nov 22, 2007·Transfusion·Brian R CurtisRichard H Aster
Feb 7, 2013·British Journal of Haematology·Julie A PetersonRichard H Aster
Jan 31, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Anna L HutchinsonLyn Downe
Apr 18, 2018·Transfusion·Jeremy Ryan PeñaBarbara O'Brien
May 23, 2017·Ŭi sahak·Youkyung Ko
Jun 11, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Sentot SantosoUlrich J Sachs
Jan 20, 2010·Rheumatology·Nicholas J Sheehan
Nov 17, 2009·Acta Paediatrica·M StarcevicV Zah-Matakovic
Jan 31, 2020·British Journal of Haematology·Ulrich J SachsGregor Bein
Nov 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gilles FoucrasFrançois Schelcher
Jul 2, 2020·Transfusion·Jesper DahlHeidi Tiller
Nov 30, 2018·Pediatric Blood & Cancer·Mitsuo OkuboAkimichi Ohsaka
Nov 20, 2016·Transfusion Medicine·E RefsumA Wikman