Neonatal alloimmune thrombocytopenia in the Irish population: a discrepancy between observed and expected cases.

Journal of Clinical Pathology
A DavorenW G Murphy

Abstract

To estimate the rate of detection of neonatal alloimmune thrombocytopenia (NAITP) in the Irish population, to investigate clinical presentation and outcome in affected infants, and to determine the extent, if any, to which this condition is underdiagnosed at present. Cases were collected in a retrospective fashion from a review of platelet serology laboratory records from January 1992 to December 2000. Clinical data were obtained from hospital records. Testing for maternal antiplatelet antibody was by one or more of the following: the platelet suspension immunofluorescence test, a commercial antigen capture enzyme linked immunosorbent assay (GTI-PakPlus), and the monoclonal antibody immobilisation of platelet antigens assay. Platelet antigen typing was by the polymerase chain reaction technique with sequence specific primers. Twenty seven serologically verified cases of NAITP were identified in 18 families. Maternal antibody to human platelet antigen 1a accounted for 25 of the 27 confirmed cases. Twenty one of 26 infants were born with severe thrombocytopenia. Nineteen of 27 infants had bleeding manifestations at birth. Petechiae and bruising were most commonly observed (n = 17). There were no documented cases of intracranial h...Continue Reading

References

Feb 18, 1989·Lancet·C Mueller-EckhardtS Santoso
Jun 1, 1995·British Journal of Haematology·H A DoughtyA H Waters
Feb 1, 1995·American Journal of Obstetrics and Gynecology·M J PaidasJ B Bussel
Nov 11, 1993·The New England Journal of Medicine·R F Burrows, J G Kelton
May 1, 1993·American Journal of Obstetrics and Gynecology·A GhidiniR Romero
Jan 1, 1996·British Journal of Haematology·H BessosW G Murphy
May 1, 1996·American Journal of Perinatology·I A Bonacossa, L J Jocelyn
May 1, 1996·The Journal of Maternal-fetal Medicine·A N KhouzamiK J Blakemore
Aug 15, 1998·Vox Sanguinis·S Santoso, V Kiefel
Sep 30, 1998·British Journal of Haematology·G P SummerfieldC Chapman
May 8, 1999·British Journal of Haematology·M F MurphyM Greaves
Sep 25, 2001·American Journal of Obstetrics and Gynecology·C M RadderH H Kanhai

❮ Previous
Next ❯

Citations

Sep 10, 2003·The Journal of Perinatal & Neonatal Nursing·Mary Ellen Burke Sosa
Jan 25, 2003·Current Opinion in Pediatrics·Irene A G Roberts, Neil A Murray
Mar 20, 2008·Obstetrical & Gynecological Survey·V M L Serrarens-JanssenE A P Steegers
Sep 14, 2012·Journal of Paediatrics and Child Health·David C RissonBronwyn A Williams
Aug 26, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·I Roberts, N A Murray
Oct 21, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Giorgio FratellanzaNicola Scarpato
Apr 11, 2008·Transfusion Medicine·C D De La Vega ElenaE Muñiz-Díaz
Jan 20, 2007·British Journal of Haematology·Michael F Murphy, James B Bussel
May 14, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Anne DavorenWilliam G Murphy
Apr 11, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·F ReganUNKNOWN Royal College of Obstetricians and Gynaecologists
Dec 13, 2002·Acta Paediatrica. Supplement·N A Murray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.