Neonatal alloimmune thrombocytopenia with HLA alloimmunization: case report with immunohematologic and placental findings

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Michael W De TarThomas Rau

Abstract

Severe neonatal thrombocytopenia is associated with a significant risk of neonatal bleeding complications. It may result from increased consumption, increased destruction, deficient production, or abnormal sequestration within the spleen. When immune mediated, most cases of clinically significant neonatal thrombocytopenia are due to maternal alloimmunization to paternally derived platelet antigens present on fetal platelets. We present the clinical, placental, and immunohematologic findings of a case of severe neonatal alloimmune thrombocytopenia (NAITP) complicated by additional HLA group alloimmunization. The placenta showed chronic villitis of unknown etiology (VUE) and diffuse microthrombi within the villous capillaries, indicating that abnormal thrombogenesis can be a complication of severe NAITP.

Citations

Aug 26, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·I Roberts, N A Murray
Jan 25, 2003·Current Opinion in Pediatrics·Irene A G Roberts, Neil A Murray
Nov 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gilles FoucrasFrançois Schelcher
Nov 14, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Ewa BrojerKrystyna Maślanka
Aug 22, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Raymond W Redline, Sanjita Ravishankar
Nov 18, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Raymond W RedlineC Maureen Sander
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