Abstract
Industrially produced trans-fatty acids (TFAs) consumed in Western diets are incorporated into maternal and fetal tissues and are passed linearly to offspring via breast milk. We hypothesized that TFA exposure in utero and during lactation in infants would promote obesity and poor glycemic control as compared with unmodified fatty acids. We further hypothesized that in utero exposure alone may program for these outcomes in adulthood. To test this hypothesis, we fed female C57/BL6 mice identical Western diets that differed only in cis- or trans-isomers of C18:1 and then aimed to determine whether maternal transfer of TFAs through pregnancy and lactation alters growth, body composition, and glucose metabolism. Mice were unexposed, exposed during pregnancy, during lactation, or throughout pregnancy and lactation to TFA. Body weight and composition (by computed tomography) and glucose metabolism were assessed at weaning and adulthood. Trans-fatty acid exposure through breast milk caused significant early growth retardation (P < .001) and higher fasting glucose (P = .01), but insulin sensitivity was not different. Elevated plasma insulin-like growth factor-1 in mice consuming TFA-enriched milk (P = .02) may contribute to later catch...Continue Reading
References
Nov 1, 1992·Lipids·B B TeterM Keeney
Apr 1, 1992·Acta Paediatrica·B Koletzko
Oct 1, 1990·Journal of the American College of Nutrition·M G EnigJ Sampugna
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·C H KnightA H Docherty
Dec 10, 1999·Bioscience, Biotechnology, and Biochemistry·N AokiT Matsuda
Feb 7, 2001·BMJ : British Medical Journal·K K OngD B Dunger
Jan 5, 2002·Early Human Development·E LarquéA Gil
Jan 28, 2004·Circulation·Scott M GrundyUNKNOWN National Heart, Lung, and Blood Institute
May 18, 2004·Lancet·Atul Singhal, Alan Lucas
Feb 3, 2005·Pediatrics·Lawrence M GartnerUNKNOWN American Academy of Pediatrics Section on Breastfeeding
Feb 8, 2005·The Journal of Physiology·James A ArmitageLucilla Poston
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Apr 1, 2005·Obesity Research·Chaoyang LiJasjit S Ahluwalia
May 23, 2006·Atherosclerosis. Supplements·Sheila M Innis
May 23, 2006·Atherosclerosis. Supplements·Margaret C Craig-Schmidt
Aug 1, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Frits A J MuskietMijna Hadders-Algra
Jul 20, 2007·Obesity·Kylie KavanaghLawrence L Rudel
Jul 20, 2007·The Proceedings of the Nutrition Society·D B DungerK K Ong
Aug 19, 2007·The British Journal of Nutrition·Stéphanie A BayolNeil C Stickland
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Jeff HollyJulian Shield
May 10, 2008·The Journal of Physiology·S A BayolN C Stickland
Jul 16, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R A WaterlandS Mirza
Aug 23, 2008·Obesity·Youfa WangShiriki K Kumanyika
Aug 30, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L J PriorM J Morris
Citations
May 8, 2013·Disease Models & Mechanisms·Jessica L BuescherJennifer G Duncan
Feb 15, 2013·PloS One·Mirjam LuijtenThomas B Knudsen
Nov 7, 2013·Journal of Nutrition and Metabolism·Noriko KomatsuzakiYoko Nakashima
Jan 24, 2014·Journal of Diabetes Research·Xinli JiangYan Liu
Oct 3, 2014·Mediators of Inflammation·Carina Almeida MoraisLuciana Pellegrini Pisani
Apr 14, 2016·Lipids in Health and Disease·José Flores-SierraGertrud Lund
Aug 16, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marnie G SilversteinKylie Kavanagh
Oct 31, 2012·The Journal of Nutritional Biochemistry·Samuel P HoileGraham C Burdge
Dec 3, 2014·The Journal of Nutritional Biochemistry·Laís V MennittiLuciana P Pisani
Feb 23, 2017·The British Journal of Nutrition·Louise GatesAndrew M Salter
Aug 18, 2017·Journal of Cellular Biochemistry·Leilei GuHui Zhu
Aug 31, 2012·The Journal of Clinical Endocrinology and Metabolism·Tanja G M VrijkotteMarcel B Twickler
May 30, 2019·Medicina·Līva AumeistereKristīne Ceļmalniece
Nov 5, 2020·Journal of Clinical Lipidology·Rui-Hong XueHe-Feng Huang
Jul 18, 2021·Veterinary Medicine and Science·YanHong LiSongJia Lai