Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice.

Nutrition Research
Kylie KavanaghLawrence L Rudel

Abstract

Industrially produced trans-fatty acids (TFAs) consumed in Western diets are incorporated into maternal and fetal tissues and are passed linearly to offspring via breast milk. We hypothesized that TFA exposure in utero and during lactation in infants would promote obesity and poor glycemic control as compared with unmodified fatty acids. We further hypothesized that in utero exposure alone may program for these outcomes in adulthood. To test this hypothesis, we fed female C57/BL6 mice identical Western diets that differed only in cis- or trans-isomers of C18:1 and then aimed to determine whether maternal transfer of TFAs through pregnancy and lactation alters growth, body composition, and glucose metabolism. Mice were unexposed, exposed during pregnancy, during lactation, or throughout pregnancy and lactation to TFA. Body weight and composition (by computed tomography) and glucose metabolism were assessed at weaning and adulthood. Trans-fatty acid exposure through breast milk caused significant early growth retardation (P < .001) and higher fasting glucose (P = .01), but insulin sensitivity was not different. Elevated plasma insulin-like growth factor-1 in mice consuming TFA-enriched milk (P = .02) may contribute to later catch...Continue Reading

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Citations

May 8, 2013·Disease Models & Mechanisms·Jessica L BuescherJennifer G Duncan
Jan 24, 2014·Journal of Diabetes Research·Xinli JiangYan Liu
Apr 14, 2016·Lipids in Health and Disease·José Flores-SierraGertrud Lund
Aug 16, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marnie G SilversteinKylie Kavanagh
Oct 31, 2012·The Journal of Nutritional Biochemistry·Samuel P HoileGraham C Burdge
Dec 3, 2014·The Journal of Nutritional Biochemistry·Laís V MennittiLuciana P Pisani
Aug 31, 2012·The Journal of Clinical Endocrinology and Metabolism·Tanja G M VrijkotteMarcel B Twickler
May 30, 2019·Medicina·Līva AumeistereKristīne Ceļmalniece

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