Neonatal and Obstetrical Outcomes of Pregnancies in Systemic Lupus Erythematosus

Oman Medical Journal
Reem AbdwaniIbrahim Al-Zakwani

Abstract

Systemic lupus erythematous (SLE) is a chronic autoimmune disease that affects women primarily of childbearing age. The objective of this study was to determine the neonatal and maternal outcomes of pregnancies in SLE patients compared to pregnancies in healthy controls. We conducted a retrospective cohort study in a tertiary care hospital in Oman between January 2007 and December 2013. We analyzed 147 pregnancies and compared 56 (38.0%) pregnancies in women with SLE with 91 (61.9%) pregnancies in healthy control women. Disease activity was determined using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The mean age of the cohort was 30.0±5.0 years ranging from 19 to 44 years old. Patients with SLE were treated with hydroxychloroquine (n = 41; 73.2%), prednisolone (n = 38; 67.8%), and azathioprine (n = 17; 30.3%). There was no disease activity in 39.2% (n = 22) of patients while 41.0% (n = 23), 12.5% (n = 7), and 7.1% (n = 4) had mild (SLEDAI 1-5), moderate (SLEDAI 6-10), and severe (SLEDAI 3 11) disease activity, respectively, at onset of pregnancy. Pregnancies in patients with SLE were associated with higher abortions (42.8% vs. 15.3%; p < 0.001), gestational diabetes (28.3% vs. 10.2%; p = 0.004), polyhydra...Continue Reading

Citations

Dec 14, 2018·Frontiers in Neurology·Yue LiBitao Bu
Dec 1, 2020·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Rahana Abd RahmanAni Amelia Zainuddin
Aug 5, 2021·Journal of Tropical Pediatrics·Pattima PakhathirathienGunlawadee Maneenil
Sep 15, 2021·Clinical Reviews in Allergy & Immunology·António BragaJorge Braga
Nov 19, 2020·Pediatrics·Lesley A TarasoffHilary K Brown

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