Abstract
We measured neonatal apo A-I and apo B by ELISA, and apo(a) by RIA, in capillary blood spotted onto filter paper in samples also used for routine neonatal screening in 1032 consecutively born babies. In the 2- to 5-d-old babies with birth weights greater than or equal to 2.0 kg (n = 919), mean +/- SD levels of apo A-I and B were 0.48 +/- 0.19 g/L and 0.24 +/- 0.14 g/L of whole blood, respectively. The apo A-I levels were affected by birth weight (negatively) and by age at sampling (positively). The apo B levels were affected positively by both variables, and girls had higher levels than boys (p less than 0.01). These variables accounted for 3.5 and 6.2% of apo A-I and apo B variability, respectively (p less than 0.001). The apo(a) levels (mean +/- SD, 20 +/- 23 U/L; median, 14 U/L, n = 1032) were unaffected by these factors. After adjustment for these variables, apo A-I levels were nearly normally distributed, whereas those of apo B were still positively skewed. The apo(a) distribution was strongly positively skewed and 1.2% of babies had levels above the equivalent of 25 mg/dL of lipoprotein(a) in serum. Our study shows that blood spots can be used to estimate apo A-I, apo B, and apo(a) levels in neonates, and establishes norm...Continue Reading
Citations
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