PMID: 6537974Jan 1, 1984Paper

Neonatal bilirubin production estimated from "end-tidal" carbon monoxide concentration

Journal of Pediatric Gastroenterology and Nutrition
D W SmithDavid K Stevenson

Abstract

The relationship between the pulmonary excretion rate of carbon monoxide (VECO) and the concentration of CO, in a sample of breath, drawn through a nasopharyngeal catheter at end-expiration, was assessed in 25 studies of nine preterm and 14 term infants. The VECO and this approximate end-tidal sample of CO (ETCO) correlated significantly over a wide range of CO elimination rates: VECO = 10.45 ETCO + 2.25 (n = 25, r = 0.95). The ETCO correctly predicted elevations in VECO greater than 2 SD of the mean VECO for normal infants (13.9 +/- 3.5 microliter/kg/h), with 90% sensitivity and 73% specificity (p less than 0.01). Three subjects with Rh isoimmune hemolytic disease were easily identified by the ETCO as well as the VECO. The ETCO is a simple, noninvasive measurement for rapidly identifying infants with significant hemolytic disease.

Citations

Jul 27, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·H OkuyamaH Nakamura
Aug 24, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·D K Stevenson
Jun 7, 2011·Seminars in Perinatology·David K StevensonRonald J Wong
Jan 7, 2015·Seminars in Fetal & Neonatal Medicine·Ronald J Wong, David K Stevenson
Sep 11, 2007·Physiological Measurement·Rolf R Engel, Gerald Popelka
Jan 23, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·D K StevensonS R Hintz
Jan 23, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·B W YoungY C Lo
Oct 10, 1998·Journal of Paediatrics and Child Health·G C ChanC Y Yeung
Dec 15, 2020·Seminars in Perinatology·Lizhong DuVinod K Bhutani

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