Neonatal bladder inflammation produces functional changes and alters neuropeptide content in bladders of adult female rats.

The Journal of Pain : Official Journal of the American Pain Society
Jennifer DeBerryTimothy J Ness

Abstract

Neonatal bladder inflammation has been demonstrated to produce hypersensitivity to bladder re-inflammation as an adult. The purpose of this study was to investigate the effects of neonatal urinary bladder inflammation on adult bladder function and structure. Female Sprague-Dawley rats were treated on postnatal days 14 to 16 with intravesical zymosan or anesthesia alone. At 12 to 16 weeks of age, micturition frequency and cystometrograms were measured. Similarly treated rats had their bladders removed for measurement of plasma extravasation after intravesical mustard oil, for neuropeptide analysis (calcitonin gene-related peptide or Substance P) or for detailed histological examination. Rats treated with zymosan as neonates exhibited increased micturition frequency, reduced micturition volume thresholds, greater extravasation of Evans blue after intravesical mustard oil administration, and greater total bladder content of calcitonin gene-related peptide and Substance P. In contrast, there were no quantitative histological changes in the thickness, fibrosis, or mast cells of bladder tissue due to neonatal zymosan treatments. Functional changes in urologic systems observed in adulthood, coupled with the increased neuropeptide cont...Continue Reading

References

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·T J ChristmasR T Turner-Warwick
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·M MichaelisW Jäenig
May 1, 1997·Urology·C A Jones, L Nyberg
Feb 25, 2000·The Journal of Urology·R PeekerF Aldenborg
Jun 10, 2000·Science·C J Woolf, M W Salter
Mar 14, 2003·Journal of Neurophysiology·Yuan Bo PengDaniel R Kenshalo
Apr 24, 2004·The Journal of Pain : Official Journal of the American Pain Society·K LambK Bielefeldt
Jul 5, 2005·Nature Reviews. Neuroscience·Maria Fitzgerald
Dec 6, 2005·The Journal of Pain : Official Journal of the American Pain Society·Andrea G HohmannAndrea G Nackley
Jan 20, 2006·The European Journal of Neuroscience·Gareth HathwayMaria Fitzgerald
Jul 4, 2006·The Journal of Pain : Official Journal of the American Pain Society·Alan RandichTimothy J Ness
Apr 28, 2007·Urology·Grannum R SantTheoharis C Theoharides
Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C SmithA Miranda
Sep 13, 2007·Neurourology and Urodynamics·Phillip P SmithGeorge T Somogyi
Mar 1, 2008·BJU International·Pierangelo GeppettiSilvia Benemei
Apr 24, 2008·British Journal of Anaesthesia·S M Walker
Jul 12, 2008·Behavioral and Brain Functions : BBF·Jing WangElie D Al-Chaer
Dec 20, 2008·Pain·Iris Wollgarten-HadamekChristiane Hermann

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Citations

Aug 18, 2012·PloS One·Charles N RudickDavid J Klumpp
May 20, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A MirandaJ N Sengupta
Feb 6, 2014·The European Journal of Neuroscience·Fred Schwaller, Maria Fitzgerald
Feb 13, 2018·Frontiers in Systems Neuroscience·Isabella M Fuentes, Julie A Christianson
May 28, 2019·Trauma, Violence & Abuse·Autumn M GallegosWilfred R Pigeon
Jan 3, 2014·Physiological Reviews·Martin S SteinhoffNigel W Bunnett
Apr 25, 2020·Neurourology and Urodynamics·Timothy J NessXin Su
Jan 9, 2019·Frontiers in Neuroscience·Luke GrundyStuart M Brierley
Oct 6, 2021·BMC Urology·Timothy J NessKeith Hildebrand

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