Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18-22 mo of age: an MRI and DTI study

Pediatric Research
Jessica RoseNaama Barnea-Goraly

Abstract

Near-term brain structure was examined in preterm infants in relation to neurodevelopment. We hypothesized that near-term macrostructural brain abnormalities identified using conventional magnetic resonance imaging (MRI), and white matter (WM) microstructure detected using diffusion tensor imaging (DTI), would correlate with lower cognitive and motor development and slower, less-stable gait at 18-22 mo of age. One hundred and two very-low-birth-weight preterm infants (≤1,500 g birth weight; ≤32 wk gestational age) were recruited prior to routine near-term brain MRI at 36.6 ± 1.8 wk postmenstrual age. Cerebellar and WM macrostructure was assessed on conventional structural MRI. DTI was obtained in 66 out of 102 and WM microstructure was assessed using fractional anisotropy and mean diffusivity (MD) in six subcortical brain regions defined by DiffeoMap neonatal atlas. Neurodevelopment was assessed with Bayley-Scales-of-Infant-Toddler-Development, 3rd-Edition (BSID-III); gait was assessed using an instrumented mat. Neonates with cerebellar abnormalities identified using MRI demonstrated lower mean BSID-III cognitive composite scores (89.0 ± 10.1 vs. 97.8 ± 12.4; P = 0.002) at 18-22 mo. Neonates with higher DTI-derived left posteri...Continue Reading

References

May 1, 1967·The Journal of Psychology·A A Baumeister, G Kellas
Dec 1, 1996·Radiology·C PierpaoliG Di Chiro
Aug 18, 2006·The New England Journal of Medicine·Lianne J WoodwardTerrie E Inder
Sep 12, 2006·Seminars in Fetal & Neonatal Medicine·Petra S Hüppi, Jessica Dubois
Oct 28, 2008·Brain : a Journal of Neurology·Serena J CounsellFrances M Cowan
May 1, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·P K Maulik, G L Darmstadt
May 23, 2009·Developmental Medicine and Child Neurology·Jessica RoseDavid K Stevenson
Aug 29, 2009·Trends in Neurosciences·Steven P Miller, Donna M Ferriero
Oct 22, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·S HorschM Blennow
Feb 19, 2010·Developmental Medicine and Child Neurology·Ghada BeainoUNKNOWN EPIPAGE Study Group
Jul 21, 2011·Cerebral Cortex·Gareth BallSerena J Counsell
Oct 22, 2011·Developmental Medicine and Child Neurology·Alicia J SpittlePeter J Anderson
Jan 4, 2012·Developmental Medicine and Child Neurology·Britt J M Van KooijFloris Groenendaal
May 25, 2012·AJR. American Journal of Roentgenology·James M ProvenzaleSteven Chen
Sep 11, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Gareth BallSerena J Counsell
Nov 14, 2012·Cerebral Cortex·Catherine LimperopoulosAdré J du Plessis
Feb 28, 2013·Developmental Medicine and Child Neurology·Francisca T De BruïneJeroen Van Der Grond
Jun 26, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kenichi OishiSusumu Mori
Jul 24, 2013·Pediatrics·Ayoub MithaUNKNOWN EPIPAGE Study Group
Jan 3, 2015·Pediatrics·Susan R HintzUNKNOWN SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research

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Citations

Apr 4, 2017·Frontiers in Human Neuroscience·Joanne ZhouJessica Rose
Jan 20, 2018·Developmental Medicine and Child Neurology·Aurelie PascalChristine Van den Broeck
Sep 30, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Chandler Rebecca Lee MongersonDusica Bajic
Aug 1, 2020·Frontiers in Human Neuroscience·Eirini PapageorgiouEls Ortibus
Jul 28, 2019·Pediatric Research·Katherine M OttoliniCatherine Limperopoulos
May 27, 2017·Molecular Neurobiology·Till ScheuerThomas Schmitz
Sep 10, 2016·Journal of Pediatric Rehabilitation Medicine·Patty Coker-BoltDorothea Jenkins
Mar 7, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Claire E KellyJeanie Ly Cheong
Jun 3, 2021·NeoReviews·Katherine M OttoliniCatherine Limperopoulos
Oct 10, 2020·NeuroImage. Clinical·Sarah E DubnerKatherine E Travis
Jul 30, 2021·Human Brain Mapping·Rahul ChandwaniUNKNOWN Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Group

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