Neonatal Candida auris infection: Management and prevention strategies - A single centre experience

Journal of Paediatrics and Child Health
Jayasree ChandramatiSasidharan Ponthenkandath

Abstract

Our aim was to identify the clinical features and outcome of multidrug resistant Candida auris (CA) infection in neonates. This is a retrospective case cohort study of 17 neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive care unit over 3 years. The risk factors, clinical features, treatment and outcome were studied. The mean gestation was 32.4 ± 4.9 weeks with overall mortality of 41%. Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to micafungin but resistant to fluconazole and had variable sensitivity to voriconazole and amphotericin. Survival improved to 83% when infants were treated with a combination of micafungin and amphotericin. Non-survivors were of lower birthweights and had other risk factors. The management guidelines and infection control measures are described in this largest series of neonatal CA infection. Treatment with a combination of amphotericin and micafungin improved the outcome.

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Citations

Apr 29, 2021·Indian Journal of Medical Microbiology·Gurujala Mahadeva RamyaR UshaDevi
Jun 20, 2021·Revista iberoamericana de micología·Alba Ruiz-Gaitán, José Luis Del Pozo
Jul 16, 2021·Current Opinion in Infectious Diseases·Brandon R Hadfield, Joseph B Cantey

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