PMID: 7521945Apr 25, 1994Paper

Neonatal capsaicin treatment in rats results in scratching behavior with skin damage: potential model of non-painful dysesthesia

Neuroscience Letters
D A ThomasM A Ruda

Abstract

We administered capsaicin or vehicle in 2-day-old rat pups, and for over 6 months examined the rats for damaged skin and for the behaviors of scratching, gnawing and biting their skin. By 35 days of age, all rats in the capsaicin group (n = 10) had damaged skin (i.e., lesions, hair loss and red skin) on the rostral half of their bodies. Skin damage remained prevalent over 6 months, whereas vehicle-treated rats (n = 8) had virtually no skin damage. Gnawing and biting behaviors were rarely observed, however, rats in the capsaicin group frequently scratched themselves. There was a significant positive correlation between the frequency at which rats scratched themselves and the total area of skin damage. Morphine (3.0 mg/kg, i.p.) greatly increased scratching behavior in only the capsaicin-treated rats and naloxone (0.5 mg/kg, i.p.) significantly reduced scratching in these rats. Thus, neonatal capsaicin, in its destruction of the majority of primary afferent C-fibers, is capable of inducing opioid-sensitive scratching behavior.

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Citations

Jan 1, 1995·Peptides·G A OlsonA J Kastin
Jan 29, 2011·Neuropeptides·Sarah-Jane Smillie, Susan D Brain
Apr 24, 2009·The Journal of Pain : Official Journal of the American Pain Society·Minna M HamalainenTimothy J Brennan
Dec 30, 2014·Journal of Magnetic Resonance Imaging : JMRI·Keun-Yeong Jeong, Ji-Hyuk Kang
Jul 23, 2004·Physiological Reviews·Susan D Brain, Andrew D Grant
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
May 6, 2020·International Journal of Molecular Sciences·Keun-Yeong Jeong
Jun 11, 1999·The American Journal of Physiology·D MichaudZ Merali

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