Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats.

ACS Chemical Neuroscience
Tori L SchaeferMichael T Williams

Abstract

Neonatal exposure to 3,4-methylenedioxymethamphetamine (MDMA) produces long-term learning and memory deficits and increased anxiety-like behavior. The mechanism underlying these behavioral changes is unknown but we hypothesized that it involves perturbations to the serotonergic system as this is the principle mode of action of MDMA in the adult brain. During development 5-HT is a neurotrophic factor involved in neurogenesis, synaptogenesis, migration, and target region specification. We have previously showed that MDMA exposure (4×10 mg/kg/day) from P11-20 (analogous to human third trimester exposure) induces ~50% decreases in hippocampal 5-HT throughout treatment. To determine whether MDMA-induced 5-HT changes are determinative, we tested if these changes could be prevented by treatment with a selective serotonin reuptake inhibitor (citalopram: CIT). In a series of experiments we evaluated the effects of different doses and dose regimens of CIT on MDMA-induced 5-HT depletions in three brain regions (hippocampus, entorhinal cortex, and neostriatum) at three time-points (P12, P16, P21) during the treatment interval (P11-20) known to induce behavioral alterations when animals are tested as adults. We found that 5 mg/kg CIT admini...Continue Reading

References

Jan 1, 1978·Developmental Neuroscience·J M Lauder, H Krebs
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G Rudnick, S C Wall
Jan 1, 1992·Physiological Reviews·B L Jacobs, E C Azmitia
Jan 1, 1990·Annals of the New York Academy of Sciences·J M Lauder
May 1, 1988·Behavioral and Neural Biology·D Cook, R P Kesner
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·K Fredricson Overø
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Jul 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E T Leonardi, E C Azmitia
Jan 1, 1996·Behavioural Brain Research·P M Whitaker-AzmitiaJ M Lauder
Feb 20, 1997·Brain Research. Developmental Brain Research·W YanJ H Haring
Mar 28, 1998·The European Journal of Neuroscience·S LinnarssonP Ernfors
Jul 31, 1999·Neuropharmacology·T S ZetterströmD G Grahame-Smith
Oct 30, 1999·Lancet·P R McElhattonS H Thomas
Aug 3, 2001·Neuroscience·B ClancyB L Finlay
Jul 2, 2003·Physiology & Behavior·Jon E SpragueBrian Woodside
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Mar 10, 2004·International Review of Neurobiology·Monsheel S K Sodhi, Elaine Sanders-Bush
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amelia A Russo-NeustadtMichael J Chen
Jul 2, 2004·Therapeutic Drug Monitoring·Rafael de la TorreJordi Camí
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Charles V VorheesMichael T Williams
Sep 29, 2004·Neurotoxicology and Teratology·Michael T WilliamsCharles V Vorhees
May 17, 2005·Pharmacology, Biochemistry, and Behavior·David P DaberkowKristen A Keefe
Jun 18, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Minke E JongsmaJohan A den Boer
Jul 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dorota MaciagIan A Paul
Mar 15, 2006·Neurology·Konstantine K Zakzanis, Zachariah Campbell
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark C Fuhs, David S Touretzky

❮ Previous
Next ❯

Citations

Jan 12, 2013·The International Journal of Neuropsychopharmacology·Tori L SchaeferCharles V Vorhees
Sep 29, 2018·Minerva ginecologica·Elena SkokoSoo Downe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.