PMID: 8947942Nov 1, 1996Paper

Neonatal cocaine and/or ethanol exposure: effects on a runway task with suckling reward

Neurotoxicology and Teratology
L S Hansen-TrenchS Barron

Abstract

This experiment employed a rodent model to examine the effects of neonatal exposure to cocaine, ethanol, or both drugs in combination on acquisition and extinction of an appetitive runway task. After implantation with an intragastric cannula, subjects were artificially reared (AR) from postnatal days (PND) 4-10. There were five treatment groups, including: cocaine (20 mg/kg/day), ethanol (4 g/kg/ day), cocaine/ethanol (20 mg/kg/day cocaine and 4 g/kg/day ethanol), stock (an AR control), and sham (a suckled control). Subjects were tested on PND 13-14. The runway task consisted of traversing a runway for nonnutritive suckling on an anesthetized dam and a subsequent milk reward, given manually by the experimenter. Pups from all treatment groups acquired and extinguished the runway task; however, pups exposed to cocaine had longer latencies to leave the start box than controls. Pups exposed to cocaine or ethanol, but not cocaine/ethanol, were impaired on the nipple attachment measures compared to sham controls. These results provide further support that the "third trimester" is a sensitive period for developmental drug exposure.

References

Mar 1, 1979·Early Human Development·J Dobbing, J Sands
Oct 1, 1979·Acta Psychiatrica Scandinavica·G LarssonR Zetterström
Sep 8, 1977·The New England Journal of Medicine·E M OuelletteL Weiner
Nov 27, 1975·Nature·W G HallE M Blass
May 1, 1992·The Journal of Pediatrics·I Autti-RämöM L Granström
Sep 1, 1992·Neurotoxicology and Teratology·P J Bilitzke, M W Church
Jul 1, 1991·Neurotoxicology and Teratology·G A Richardson, N L Day
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·S BarronE P Riley
May 1, 1991·American Journal of Obstetrics and Gynecology·A P StreissguthL Moore
May 1, 1990·Neurotoxicology and Teratology·C D DriscollE P Riley
Sep 1, 1989·American Journal of Obstetrics and Gynecology·R F HumeJ L Gingras
Jan 1, 1989·Neurotoxicology and Teratology·R F SmithS L Kurtz
Jul 1, 1988·Neurotoxicology and Teratology·M W ChurchP K Gessner
Dec 1, 1988·Pharmacology, Biochemistry, and Behavior·R W Foltin, M W Fischman
Oct 1, 1987·The Journal of Pediatrics·A S Oro, S D Dixon
Apr 1, 1986·Teratology·G A Rockwood, E P Riley
Jul 1, 1973·Developmental Psychobiology·H Abbey, E Howard
Jun 1, 1982·Clinical Pediatrics·D C Van DykeE N Ziaylek
Sep 1, 1980·Developmental Psychobiology·J S Chen, A Amsel
Jan 1, 1995·Pharmacology, Biochemistry, and Behavior·S Barron, J Irvine
Jan 1, 1993·Psychopharmacology·S T HigginsM A Capeless
Jan 1, 1994·Neurotoxicology and Teratology·S Barron, J Irvine
Sep 1, 1993·Neurotoxicology and Teratology·P M KunkoS E Robinson
Apr 1, 1993·Drug and Alcohol Dependence·R W FoltinT H Kelly
Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·S BarronT M Segar
Jan 1, 1996·Behavioural Brain Research·S BarronD H Kaiser

❮ Previous
Next ❯

Citations

Nov 26, 1999·Developmental Psychobiology·J A WillfordS Barron
Mar 25, 1998·Neurotoxicology and Teratology·V P MarkowskiB Weiss
Aug 11, 1998·Neurotoxicology and Teratology·S BarronL S Hansen-Trench
Feb 24, 1999·Alcoholism, Clinical and Experimental Research·T M SegarS Barron
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·S J CheslockN E Spear
Feb 1, 2005·Neurotoxicology and Teratology·Lynne S Hansen-Trench, Susan Barron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.