PMID: 697532Jun 1, 1978Paper

Neonatal detection of hypothyroidism in the South-Pyrenean region. Results of 14,000 determinations of T4 in blood eluates collected on blotting-paper

Archives françaises de pédiatrie
P RochiccioliP Enjaume

Abstract

Screening for neonatal hypothyroidism has been undertaken in Southern France by the estimation of T4 in the eluates of blood spots on filter paper. Since March 1976, 14,000 estimations have been made and four cases of hypothyroidism with very low levels of T4 have been detected (less than 38 pg/2 spots). Two cases had high TSH levels (greater than 200 microunits/2 spots). Blood was taken from the hypothyroid babies on the 20th day of life, to check the findings and in all cases the thyroxine was less than 2.8 microgrammes/100 ml and the TSH greater than 40 microunits/ml. T3 was reduced in three cases (less than 75 pg/ml) and normal in one case (150 pg/ml). In all cases no thyroid tissue could be demonstrated with technitium scan. In the first month of life there were practically no symptoms except for mottling of the skin in two cases, a large posterior fontanelle in two cases and in one baby a prolonged neonatal jaundice.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.