Neonatal dexamethasone therapy: short- and long-term consequences

Trends in Endocrinology and Metabolism : TEM
Hershel Raff

Abstract

The discovery of the adrenal steroid hormones was one of the momentous events of science and medicine in the 20th century, highlighted by the awarding of the Nobel Prize in Physiology or Medicine to Kendall, Reichstein and Hench in 1950. Therapy using endogenous and synthetic corticosteroids was thought to be a miracle cure for several illnesses. We now recognize the many short- and long-term side effects of glucocorticoid therapy in neonates, children and adults, including growth retardation, insulin resistance, metabolic disturbances, cognitive and psychological problems, rapidly-progressing and profound osteoporosis, and iatrogenic Cushing's syndrome. Significant attention is now being paid to the long-term consequences of glucocorticoid therapy in premature and full-term neonates.

References

Sep 1, 1996·Endocrinology and Metabolism Clinics of North America·D B Allen
Feb 5, 2002·Pediatrics·UNKNOWN Committee on Fetus and Newborn
Jun 7, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ping C LeeHershel Raff
Jan 23, 2003·Reproduction, Nutrition, Development·Muriel BonnetYves Chilliard
Mar 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jing HeSherin U Devaskar
Mar 27, 2004·The New England Journal of Medicine·Tsu F YehCheng H Tsai

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Citations

Jun 3, 2005·The Journal of Endocrinology·Eric D BruderHershel Raff
Feb 7, 2007·The Journal of Endocrinology·Hershel Raff, Lauren Jacobson
Dec 2, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ruth R JamesonTheodore A Slotkin
Mar 12, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Beth W CooperAndrew D Wallace
Oct 16, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xin ChengXuesong Yang
Aug 12, 2009·Journal of Animal Physiology and Animal Nutrition·E SliwaT Piersiak
Jun 21, 2005·Lancet·Deborah P Merke, Stefan R Bornstein
Oct 7, 2014·Toxicology and Applied Pharmacology·Xin ChengXuesong Yang
Sep 12, 2009·Pediatric Research·Willem B de VriesMatthijs F M van Oosterhout
Nov 16, 2004·Journal of Applied Physiology·Eric D BruderHershel Raff
Sep 22, 2007·Reviews in Endocrine & Metabolic Disorders·Felix G Riepe, Wolfgang G Sippell
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Theodore A SlotkinFrederic J Seidler
Jan 19, 2010·Pharmacological Reports : PR·Krzysztof WedzonyMarzena Maćkowiak
Dec 31, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric D BruderHershel Raff

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