PMID: 18203892Jan 22, 2008Paper

Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behavior

The Journal of Nutrition
Wilson G PondE O'Brian Smith

Abstract

This experiment was designed to test the effect of polymorphism in the cholesterol 7-alpha hydroxylase (CYP7) gene locus and dietary cholesterol (C) on cerebrum C in neonatal pigs fed sow's milk formulas. Thirty-six pigs (18 male and 18 female) genetically selected for high (HG) or low (LG) plasma total C were weaned at 24-36 h after birth and assigned in a 2 x 2 x 2 factorial arrangement of treatments with 2 diets (0 or 0.5% C), 2 sexes, and 2 genotypes (HG and LG). Individually housed pigs consumed diets ad libitum for 42 d. Open-field behavior was tested at wk 2 and 4. All pigs were killed at 42 d of age, the cerebrum was weighed, and C content and concentration measured. All data were analyzed by general linear model ANOVA. Cerebrum weight was greater in HG than LG pigs (P < 0.03) but was not affected by diet or sex. Pigs fed C tended to have a higher cerebrum C concentration than those deprived (P = 0.12). At 2 wk, LG pigs explored a novel open-field environment less often (P < 0.001) than did HG pigs. At 4 wk, some LG pigs explored the open field but fewer (P < 0.001) vs. HG pigs retreated back to the safe area. There were no genotype x diet, genotype x sex, or diet x sex interactions affecting cerebrum weight, or C conte...Continue Reading

References

Jan 1, 1976·The Journal of Heredity·M F Rothschild, A B Cahpman
Sep 1, 1992·The Journal of Nutrition·B W PattersonW G Pond
Sep 1, 1991·The Journal of Nutrition·J EdmondD H Catlin
Jun 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·W G PondL D Young
Oct 1, 1973·Archives of Disease in Childhood·J Dobbing, J Sands
Feb 1, 1980·Journal of Neurochemistry·W M Pardridge, L J Mietus
Aug 1, 1995·The Journal of Nutrition·R Uauy, I De Andraca
Feb 1, 1995·Journal of Neurochemistry·H Jurevics, P Morell
Dec 15, 1995·The Journal of Biological Chemistry·G StapletonR Lathe
Aug 25, 1997·The Journal of Cell Biology·B DehouckR Cecchelli
Apr 1, 1998·Proceedings of the Society for Experimental Biology and Medicine·A M DavisH J Mersmann
Dec 30, 1998·The Journal of Nutrition·S L BolemanW G Pond
Jan 5, 2000·The American Journal of Clinical Nutrition·R Uauy, D R Hoffman
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·W G PondD R Su
Oct 1, 1958·Journal of Neurochemistry·A N DAVISONG P WRIGHT
Oct 1, 1963·Journal of Neurochemistry· DOBBINGJ
Feb 18, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J DOBBING
Mar 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·R L SEARCY, L M BERGQUIST
Dec 3, 2003·Brain : a Journal of Neurology·Catharine R GaleChristopher N Martyn
Jan 24, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J W Dickerson, J Dobbing

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Citations

Sep 3, 2010·Journal of Pediatric Gastroenterology and Nutrition·Gaëlle BoudryRonaldo P Ferraris
Aug 25, 2010·American Journal of Physical Anthropology·Dan T A EisenbergM Geoffrey Hayes
Jan 14, 2020·Genome Génome / Conseil National De Recherches Canada·Yuanlang WangYueyun Ding
Apr 18, 2014·PloS One·Annika Maria Juul HaagensenArne Astrup
May 14, 2016·Nutrition Research Reviews·Eugeni RouraDavid Val-Laillet

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