Neonatal dopamine-rich grafts and 6-OHDA lesions independently provide partial protection from the adult nigrostriatal lesion syndrome

Behavioural Brain Research
D C Rogers, S B Dunnett

Abstract

Previous studies have shown that neonatally dopamine-depleted rats are subsensitive to dopamine antagonists and do not respond to homeostatic imbalances as adults. This suggests that these animals maintain themselves independent of the dopamine system. If this is so, they should be insensitive to treatment with adult 6-hydroxydopamine (6-OHDA) lesions. Other experiments have shown that dopamine-rich grafts in the neonatal brain will provide some protection from the severe ingestive deficits induced by bilateral 6-OHDA lesions in adulthood. Three groups of animals received either nigra grafts into the intact neonatal brain, neonatal 6-OHDA lesions, or both neonatal 6-OHDA lesions and nigra grafts. A fourth group served as sham-operated controls. Methylamphetamine and haloperidol challenges showed that the neonatally lesioned animals regulated locomotor activity, eating and drinking independent of the dopamine system. Remarkably, however, 80% of these nevertheless showed the full syndrome of aphagia, adipsia and akinesia in response to adult lesions. The grafts into intact group showed enhanced survival in that 36% of the rats were able to maintain themselves following the adult lesion. The graft into neonatally lesioned rats res...Continue Reading

References

Jun 1, 1976·Journal of Comparative and Physiological Psychology·J F MarshallE M Stricker
Nov 1, 1974·Journal of Comparative and Physiological Psychology·J F MarshallP Teitelbaum
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor

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Citations

Apr 1, 1991·Journal of Neurology·S B Dunnett
Sep 1, 1994·Progress in Neurobiology·J P Herman, N D Abrous
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Aug 31, 2000·Experimental Neurology·M D DöbrössyN Abrous
Jan 1, 1991·Developmental Psychobiology·B M Potter, J P Bruno

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