PMID: 8950734Jan 1, 1996Paper

Neonatal early onset group B streptococcal infection. A nine-year retrospective study in a tertiary care hospital

Journal of Perinatal Medicine
A H AdriaanseL A Kollée

Abstract

Retrospectively, morbidity and mortality of neonatal early onset group B streptococcal (GBS) infection were established. Risk factors and prognostic factors were determined. Between 1985 and 1993, 78 patients with early onset GBS disease were identified. The overall mortality rate was 23%. In 60 of 73 cases (82%) at least one of the investigated risk factors was present. Low birth weight was not an independent risk factor. Outcome of 44 of 60 survivors (73%) at the age of at least one year was obtained. Almost 30% of them had sequelae. The most important were spastic disorders and delayed psychomotor development. In 42% of patients with symptoms of GBS-infection within six hours after birth sequelae occurred. There were no sequelae among patients with symptoms after 6 hours. All 9 severely brain damaged infants showed symptoms shortly after birth. Mortality and adverse outcome rate were higher in infants with low gestational age or low 5 minute Apgar scores. Early treatment resulted in less mortality, but not in less sequelae. GBS-sepsis still causes significant mortality and leaves a substantial number of survivors damaged. Alertness to GBS-infection, even in the absence of risk factors, remains crucial for early treatment and...Continue Reading

Citations

Jul 9, 2013·Molecular Diagnosis & Therapy·Stéphane EmonetBegoña Martinez de Tejada
Apr 12, 2000·Journal of Paediatrics and Child Health·T WanA Tam
Jan 18, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Trijbels-SmeuldersL A A Kollée
Oct 14, 2000·Journal of Perinatal Medicine·J B López SastreUNKNOWN Grupo de Hospitales Castrillo
Jan 1, 1997·Journal of Perinatal Medicine·S BramerA H Adriaanse
Aug 12, 2014·International Journal of Environmental Research and Public Health·Begoña Martinez de Tejada
Mar 10, 2007·Seminars in Fetal & Neonatal Medicine·Karin Pettersson
Sep 24, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B Martinez de TejadaJ Schrenzel
Nov 26, 2002·Paediatric and Perinatal Epidemiology·Monique Trijbels-SmeuldersLouis A A Kollée
Dec 24, 2002·The Australian & New Zealand Journal of Obstetrics & Gynaecology·G L GilbertS R Leeder
Oct 9, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Imelda P UyRonnie Guillet
May 16, 2013·British Journal of Sports Medicine·Tone BereRoald Bahr

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