Neonatal endotoxin exposure alters the development of social behavior and the hypothalamic-pituitary-adrenal axis in selectively bred mice

Brain, Behavior, and Immunity
Douglas A GrangerM L Block

Abstract

Developmental differences in the biobehavioral consequences of immune activation in early life were investigated in two lines of mice selectively bred for high and low levels of inter-male aggressive behavior. At age 5 or 6 days, male mice were administered saline or 0.05 mg/kg gram-negative bacterial endotoxin (Escherichia coli, LPS, ip). There was a transient endotoxin-induced reduction in the growth rate of the neonates in the high-aggressive line. At age 45-50 days, the animals' behaviors were assessed in a dyadic task. Hypothalami and sera were harvested 20 min later. Rates of socially reactive behaviors to conspecific contact (i.e., kick, startle) were increased in the endotoxin-treated groups from both lines. For the high-aggressive line only, endotoxin treatment increased behavioral immobility, decreased attack frequency, and decreased levels of hypothalamic corticotrophin-releasing factor (CRF). The effects of endotoxin exposure in early life on socially reactive behaviors in later life were associated with endotoxin-induced individual differences in CRF levels in the high-aggressive line but not the low-aggressive line. The findings demonstrate long-term social developmental consequences of immune activation during th...Continue Reading

Citations

Feb 25, 2005·Behavioral Neuroscience·Staci D BilboSteven F Maier
Jun 15, 2001·ILAR Journal·R E BrownH M Schellinck
Apr 6, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·A GoverR E Grunau
Oct 17, 2012·Molecular and Cellular Neurosciences·Amaicha Mara Depino
Apr 3, 2010·Neuroscience and Biobehavioral Reviews·Michael B HennessyPatricia A Schiml-Webb
Aug 2, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·J CardasJ R Sanchez-Martín
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Soon Lee, Catherine Rivier
Jan 18, 2006·Behavioural Brain Research·Staci D BilboSteven F Maier
Feb 17, 2006·Brain, Behavior, and Immunity·Frederick R WalkerDeborah M Hodgson
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·E Ronald de KloetMathias Schmidt
Aug 11, 2004·Behavioural Brain Research·Frederick Rohan WalkerDeborah Maree Hodgson
Jul 8, 1998·Immunopharmacology and Immunotoxicology·V CovelliE Jirillo
Sep 24, 2005·Anatomy and Embryology·Arthur W Toga
Jul 30, 2010·Endocrinology·A C Kentner, Q J Pittman
Jan 4, 2017·Infant Mental Health Journal·Allan N Schore
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H AnismanZ Merali

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