The purpose of this study was to examine whether changes in extracellular matrix (ECM) molecules are associated with the growth inhibition and differentiation defects of the prostate gland following neonatal exposure to estradiol. Using immunocytochemistry (ICC), laminin and collagen IV were localized to the basement membrane (BM) as well to the basal lamina of the periductal smooth muscle of the control developing prostates. In contrast, fibronectin and collagen III were localized throughout the stromal ECM. Exposure to neonatal estrogen altered the staining profile for specific ECM molecules. In the estrogenized rats, a thick layer of cells negative for laminin and collagen IV was observed adjacent to the BM. Electron microscopy and ICC for alpha-actin, fibronectin, and vimentin identified this multicellular layer of periductal cells as differentiated fibroblasts. Peripheral to these fibroblasts, actin-positive smooth muscle formed a second layer of periductal stromal cells. PCNA labeling showed that estrogen exposure increased the fibroblast proliferation. Because many periductal fibroblasts were positive for estrogen receptor alpha (ER alpha) in estrogenized rats, a direct effect of estradiol on their proliferation is sugge...Continue Reading
Metalloproteinase activities expressed during development and maturation of the rat prostatic complex and seminal vesicles
Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression
Effect of pubertal development on estrogen receptor levels and stromal morphology in the guinea pig prostate
The differential effects of neonatal androgen, estrogen and progesterone on adult rat prostate growth
Patch clamp analysis of the dominant plasma membrane K+ channel in root cell protoplasts of Plantago media L. Its significance for the P and K state
The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen
Effects of neonatal estrogen exposure on prostatic secretory genes and their correlation with androgen receptor expression in the separate prostate lobes of the adult rat
Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses
Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes
Neonatal hypothyroidism alters the pattern of prostatic growth and differentiation, as well as plasminogen activator and metalloprotease expression, in the rat
Prostatic ductal system in rats: tissue-specific expression and regional variation in stromal distribution of transforming growth factor-beta 1
Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats
Expression of extracellular matrix components is disrupted in the immature and adult estrogen receptor β-null mouse ovary.
Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development
Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration
Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostatitis in the lateral prostate lobe of the Wistar rat
Transient neonatal estrogen exposure to estrogen-deficient mice (aromatase knockout) reduces prostate weight and induces inflammation in late life
Gonadal expression of Sf1 and aromatase during sex determination in the red-eared slider turtle (Trachemys scripta), a reptile with temperature-dependent sex determination
Differential effects of estrogen exposure on arylsulfatase B, galactose-6-sulfatase, and steroid sulfatase in rat prostate development
The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator
Pubertal exposure to ethinylestradiol promotes different effects on the morphology of the prostate of the male and female gerbil during aging
Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate
Molecular cloning and functional study of rat estrogen receptor-related receptor gamma in rat prostatic cells
Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression
Regulation of urogenital smooth muscle patterning by testosterone and estrogen during prostatic induction
Neonatal estrogen exposure alters the transforming growth factor-beta signaling system in the developing rat prostate and blocks the transient p21(cip1/waf1) expression associated with epithelial differentiation
Developmental exposure to estrogens alters epithelial cell adhesion and gap junction proteins in the adult rat prostate
Anatomical and immunohistochemical characteristics of the prostate gland in the greater cane rat (Thryonomys swinderianus)
Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice.
Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure
Developmental estrogenization: Prostate gland reprogramming leads to increased disease risk with aging.
Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.