Neonatal exposure to 17α-ethynyl estradiol (EE) disrupts follicle development and reproductive hormone profiles in female rats

Toxicology Letters
Haolin ZhangGen Watanabe

Abstract

Toxic effects induced by exposure to endocrine-disrupting chemicals during fetal and neonatal periods can be irreversible and exert effects throughout an animal's entire life. Our previous study showed that neonatal exposure to 17α-ethynyl estradiol (EE) induced irregular estrous cycle in adults. To uncover the reason for the delayed effect after neonatal exposure to EE, reproductive parameters including ovarian weight, ovarian steroidogenesis, and hormonal profiles were investigated in developing female rats. Ovarian weight decreased at postnatal days (PND) 14 and 21 after neonatal exposure to EE. Ovarian histology at PND21 showed that the ratio of follicles with a diameter >300μm decreased and the ratio of follicles with a diameter of 100-150μm increased in EE-treated ovaries, indicating that neonatal exposure to EE retarded follicular development. Moreover, the expression of P450arom increased at PND14 and the expressions of inhibin/activin subunits βA and βB decreased at PND21 in EE-treated ovaries. Consistent with the expression of P450arom, circulating levels of 17β-estradiol increased at PND14 in EE-treated animals. Furthermore, the circulating levels of luteinizing hormone (LH) also increased at PND14 in the treated ani...Continue Reading

References

Feb 18, 2016·Human Reproduction Update·R Wijayarathna, D M de Kretser

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Citations

Mar 3, 2021·Journal of Developmental Origins of Health and Disease·Vinícius Gonçalves de SouzaAna Paula Silva Perez
Feb 22, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hyekyoung Hannah You, Gwonhwa Song

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