Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats

Toxicology Letters
Marina FernándezVictoria Lux-Lantos

Abstract

Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Female Sprague-Dawley rats were injected sc from postnatal day 1 (PND1) to PND10 with BPA: 500 μg 50 μl-1oil (B500), or 50 μg 50 μl-1(B50), or 5 μg 50 μl-1(B5). Controls were injected with 50 μl vehicle during the same period. Neonatal exposure to BPA did not modify TSH levels in PND13 females, but it increased them in adults in estrus. Serum T4 was lower in B5 and B500 with regards to Control, whereas no difference was seen in T3. No significant differences were observed in TRH, TSHβ and TRH receptor expression between groups. TSH release from PPC obtained from adults in estrus was also higher in B50 with regard to Control. In vitro 24 h pre-treatment with BPA or E2increased basal TSH as well as prolactin release. On the other hand, both BPA and E2lowered the response to TRH. The results presented here show that the neonatal exposure to BPA alters the hypothalamic pituitary-thyroid axis in adult rats in ...Continue Reading

Citations

Jul 15, 2018·Journal of Molecular Endocrinology·Karen J OliveiraTania Maria Ortiga-Carvalho
Feb 29, 2020·Molecular Reproduction and Development·Jing QiuJian Yu
Jul 19, 2020·Environmental Science and Pollution Research International·Xuan ZhangXiaobo Lu
Dec 29, 2018·Autoimmunity·Gali AljadeffYehuda Shoenfeld
Dec 31, 2019·Endocrinology and Metabolism·Min Joo Kim, Young Joo Park
Apr 17, 2020·International Journal of Environmental Research and Public Health·Francesca GoriniFabrizio Bianchi
Jul 13, 2019·Environmental Research·Ya MaHuizhen Zhang
Oct 18, 2020·Environment International·Arash DerakhshanTim I M Korevaar
Mar 10, 2021·Archives of Environmental Contamination and Toxicology·Rosaria SciarrilloMaria De Falco
Jul 20, 2020·Reproductive Toxicology·Jerrold J HeindelR Thomas Zoeller
Aug 26, 2020·Molecular and Cellular Endocrinology·Jones B GraceliAnna C Denicol

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