Neonatal exposure to DDT induces increased susceptibility to pyrethroid (bioallethrin) exposure at adult age.--Changes in cholinergic muscarinic receptor and behavioural variables

Toxicology
P ErikssonA Fredriksson

Abstract

We have recently reported that DDT and the pyrethroid bioallethrin cause similar changes in the brain muscarinic cholinergic receptors (MAChR) and behavioural disturbances in the neonatal and adult mouse when given to neonatal mice during the peak of rapid brain growth. In the present study the interaction between neonatal and adult exposure to DDT and bioallethrin, respectively, is explored. Ten-day-old NMRI mice received a single low oral dose of DDT (0.5 mg/kg body wt). At adult age (5 months) the mice received bioallethrin 0.7 mg/kg body wt./day per os for 7 days. Mice used as controls received a 20% fat emulsion vehicle. The spontaneous behavioural tests revealed significant differences, both in mice treated neonatally with DDT and receiving bioallethrin as adults and in mice receiving the vehicle as neonates and bioallethrin as adults, compared with their corresponding controls. However, the behavioural changes developed in mutually opposite directions. Significant changes in MAChR, assayed in the P2 fraction of the cerebral cortex by using the muscarinic antagonist, quinuclidinyl benzilate ([3H]QNB) and agonist carbachol, was only observed in animals receiving DDT as neonates and bioallethrin as adults. The present study...Continue Reading

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Citations

Sep 17, 2013·Cell Biology and Toxicology·Timothy C Marrs, R L Maynard
May 15, 1996·Environmental Toxicology and Pharmacology·P Eriksson, A Fredriksson
Nov 14, 2002·Neurotoxicology·Mona ThiruchelvamDeborah A Cory-Slechta
Oct 30, 2001·Behavioural Brain Research·M SedelisJ P Huston
Jun 29, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Amy Lavin Williams, John M DeSesso
Jun 20, 2013·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Carol J BurnsAbby A Li
Feb 3, 2005·Environmental Health Perspectives·Timothy J ShaferKevin M Crofton
Oct 29, 2004·Developmental Neuroscience·Brian K BarlowMona Thiruchelvam
Feb 16, 2013·Reproductive Toxicology·Laura N VandenbergR Thomas Zoeller
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Apr 17, 1999·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·K MariënM Sanderson
Mar 1, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy J ShaferKatie Paul Friedman
Dec 16, 1997·Journal of Toxicology and Environmental Health·H J ClewellJ M Gearhart

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