Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood

Scientific Reports
Raphael MathieuAlain Rivard

Abstract

Adverse perinatal conditions can lead to developmental programming of cardiovascular diseases. Prematurely born infants are often exposed to high oxygen levels, which in animal models has been associated with endothelial dysfunction, hypertension, and cardiac remodeling during adulthood. Here we found that adult mice that have been transiently exposed to O2 after birth show defective neovasculariation after hindlimb ischemia, as demonstrated by impaired blood flow recovery, reduced vascular density in ischemic muscles and increased tissue damages. Ischemic muscles isolated from mice exposed to O2 after birth exhibit increased oxidative stress levels and reduced expression of superoxide dismutase 1 (SOD1) and vascular endothelial growth factor (VEGF). Pro-angiogenic cells (PACs) have been shown to have an important role for postnatal neovascularisation. We found that neonatal exposure to O2 is associated with reduced number of PACs in adults. Moreover, the angiogenic activities of both PACs and mature mouse aortic endothelial cells (MAECs) are significantly impaired in mice exposed to hyperoxia after birth. Our results indicate that neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization dur...Continue Reading

References

Jan 1, 1987·Annual Review of Physiology·P A D'Amore, R W Thompson
Jun 17, 1998·The Journal of Clinical Investigation·T MuroharaJ M Isner
Jan 13, 2001·The Annals of Thoracic Surgery·C WittnichC E Carlyle
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D FukumuraR K Jain
Jun 19, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·George D GeorgesonAranka László
Nov 16, 2002·Circulation Research·Sean P DidionFrank M Faraci
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophie-Elise MichaudAlain Rivard
Aug 4, 2004·Free Radical Biology & Medicine·Mario ComportiLucia Ciccoli
Aug 24, 2004·Circulation Research·Carmen Urbich, Stefanie Dimmeler
Oct 8, 2005·Biology of the Neonate·Ola Didrik Saugstad
Jun 30, 2006·Journal of Molecular and Cellular Cardiology·Sophie Elise MichaudAlain Rivard
Oct 7, 2006·Stem Cells·David A IngramLaura S Haneline
Jun 19, 2007·Neonatology·Ola Didrik Saugstad
Jul 21, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonas LefèvreAlain Rivard
Apr 23, 2008·Hypertension·Dong YouJean-Sébastien Silvestre
Oct 15, 2008·Hypertension·Catherine YzydorczykAnne Monique Nuyt
Jul 4, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Paola HaddadAlain Rivard
Sep 3, 2010·The Journal of Clinical Investigation·Przemyslaw SapiehaSylvain Chemtob
Sep 22, 2011·JAMA : the Journal of the American Medical Association·Casey CrumpMarilyn A Winkleby
Feb 13, 2014·The American Journal of Pathology·Esther Rieger-FackeldeyCharles V Smith
Sep 12, 2014·Early Human Development·Adam J Lewandowski, Paul Leeson
Oct 12, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Megan O'Reilly, Bernard Thébaud
Dec 9, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Thuy Mai LuuAnne-Monique Nuyt
Feb 9, 2017·Stem Cells Translational Medicine·Mariane BertagnolliThuy Mai Luu

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